For Research Use Only. Not for use in diagnostic procedures.

Store at 2-8 degree C.

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Small volumes of cTn-T elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS284504 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Cardiac Troponin T (cTn-T) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing cTn-T. The ELISA analytical biochemical technique of the MBS284504 kit is based on cTn-T antibody-cTn-T antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect cTn-T antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, cTn-T. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

30,681 Da

troponin T type 2 (cardiac)

troponin T, cardiac muscle

Troponin T, cardiac muscle

TnTc; cTnT??[Similar Products]

TNNT2_HUMAN

The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq, Jul 2008]

TNNT2: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the ***** heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal ***** heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing ***** heart. Belongs to the troponin T family. 11 isoforms of the human protein are produced by alternative splicing.

Protein type: Motor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: cytosol; sarcomere; striated muscle thin filament; troponin complex

Molecular Function: actin binding; ATPase activity; protein binding; protein binding, bridging; structural constituent of cytoskeleton; tropomyosin binding; troponin C binding; troponin I binding

Biological Process: actin crosslink formation; atrial cardiac muscle morphogenesis; cardiac muscle contraction; muscle filament sliding; negative regulation of ATPase activity; positive regulation of ATPase activity; protein heterooligomerization; regulation of heart contraction; regulation of muscle filament sliding speed; response to calcium ion; sarcomere organization; ventricular cardiac muscle morphogenesis

Disease: Cardiomyopathy, Dilated, 1d; Cardiomyopathy, Familial Hypertrophic, 2; Cardiomyopathy, Familial Restrictive, 3

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