Full Product Name
SGCA Antibody - middle region
Product Gene Name
anti-SGCA antibody
[Similar Products]
Product Synonym Gene Name
SGCA; ADL; DAG2;[Similar Products]
Antibody/Peptide Pairs
SGCA peptide (MBS3244775) is used for blocking the activity of SGCA antibody (MBS3219927)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: HVAVPPAVHI TYHAHLQGHP DLPRWLRYTQ RSPHHPGFLY GSATPEDRGL
3D Structure
ModBase 3D Structure for Q16586
Purity/Purification
Affinity purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of Human SGCA
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-SGCA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SGCA antibody
This is a rabbit polyclonal antibody against SGCA. It was validated on Western Blot
Target Description: This gene encodes a component of the dystrophin-glycoprotein complex (DGC), which is critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. Its expression is thought to be restricted to striated muscle. Mutations in this gene result in type 2D autosomal recessive limb-girdle muscular dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene.
Product Categories/Family for anti-SGCA antibody
Polyclonal; Cell Adhesion; Membrane Protein; Disease Related;
Applications Tested/Suitable for anti-SGCA antibody
Western Blot (WB)
Western Blot (WB) of anti-SGCA antibody
Host: Rabbit
Target Name: SGCA
Sample Type: 293T Whole Cell lysates
Antibody Dilution: 1.0ug/ml
NCBI/Uniprot data below describe general gene information for SGCA. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001129169
[Other Products]
NCBI GenBank Nucleotide #
NM_001135697.2
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UniProt Primary Accession #
Q16586
[Other Products]
UniProt Related Accession #
Q16586[Other Products]
NCBI Official Full Name
alpha-sarcoglycan isoform 2
NCBI Official Synonym Full Names
sarcoglycan alpha
NCBI Official Symbol
SGCA??[Similar Products]
NCBI Official Synonym Symbols
ADL; DAG2; 50DAG; DMDA2; LGMD2D; LGMDR3; SCARMD1; adhalin
??[Similar Products]
NCBI Protein Information
alpha-sarcoglycan
UniProt Protein Name
Alpha-sarcoglycan
UniProt Synonym Protein Names
50 kDa dystrophin-associated glycoprotein; 50DAG; Adhalin; Dystroglycan-2
Protein Family
Alpha-sarcoglycan
UniProt Gene Name
SGCA??[Similar Products]
UniProt Synonym Gene Names
ADL; DAG2; Alpha-SG; 50DAG??[Similar Products]
UniProt Entry Name
SGCA_HUMAN
NCBI Summary for SGCA
This gene encodes a component of the dystrophin-glycoprotein complex (DGC), which is critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. Its expression is thought to be restricted to striated muscle. Mutations in this gene result in type 2D autosomal recessive limb-girdle muscular dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
UniProt Comments for SGCA
SGCA: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Defects in SGCA are the cause of limb-girdle muscular dystrophy type 2D (LGMD2D); also known as Duchenne- like muscular dystrophy autosomal recessive type 2 or severe childhood autosomal recessive muscular dystrophy (SCARMD). LGMD2D is an autosomal recessive degenerative myopathy characterized by progressive muscle wasting from early childhood with loss of independent ambulation by teenage years. Muscle biopsy shows necrosis, decreased immunostaining for alpha sarcoglycan, and adhalin deficiency. The phenotype is less severe than LGMD2C. Belongs to the sarcoglycan alpha/epsilon family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: dystrophin-associated glycoprotein complex; cytoskeleton; cytoplasm; integral to membrane; sarcoglycan complex; intercellular junction; sarcolemma; lipid raft
Molecular Function: calcium ion binding
Biological Process: muscle development; muscle contraction
Disease: Muscular Dystrophy, Limb-girdle, Type 2d
Research Articles on SGCA
1. Pathogenic mutations were found in SGCA from Egyptian families with limb-girdle muscular dystrophy.
Precautions
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Disclaimer
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