RPSA; 37 kDa laminin receptor; 37LRP; 40S ribosomal protein SA; 67LR; 67 kDa laminin receptor; 37/67 kDa laminin receptor; 67kD; ribosomal protein SA; LAMR1; LAMBR; Laminin receptor 1; LamR; NEM/1CHD4; SA; LRP/LR; Laminin binding protein; Laminin Rec...

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

67kDa Laminin Receptor Antibody detects endogenous levels of total 67kDa Laminin Receptor

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

1.0mg/mL (lot specific)

Store at -20 degree C

Small volumes of anti-RPSA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Total protein Ab

Western Blot (WB)

Western Blot: 1:1000-3000

Western blot analysis 67kDa Laminin Receptor ? using COS7 whole cell lysates

32,854 Da[Similar Products]

ribosomal protein SA

40S ribosomal protein SA

40S ribosomal protein SA

37LRP; LRP/LR; 67LR; LamR; LBP/p40??[Similar Products]

RSSA_HUMAN

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

RPSA: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Belongs to the ribosomal protein S2P family.

Protein type: Ribosomal

Chromosomal Location of Human Ortholog: 3p22.2

Cellular Component: cytoplasm; cytosol; membrane; nucleoplasm; nucleus; plasma membrane

Molecular Function: protein binding; ribosome binding; structural constituent of ribosome

Biological Process: endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); mRNA catabolic process, nonsense-mediated decay; ribosomal small subunit assembly and maintenance; rRNA export from nucleus; rRNA processing; SRP-dependent cotranslational protein targeting to membrane; translation; translational initiation; viral transcription

Disease: Asplenia, Isolated Congenital

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