TnT Human; Cardiac Troponin T Human; Troponin T cardiac muscle; TnTc; Cardiac muscle troponin T; cTnT; TNNT2; CMH2; CMPD2; MGC3889; Troponin-T

For Research Use Only. Not for use in diagnostic procedures.

Human Cardiac Tissue

Greater than 95.0% as determined by SDS-PAGE.

Human Cardiac Troponin T in 6M Urea, 250 mM NaCI, 50 mM Tris-HCI, 15mM Beta-mercaptoethanol, 1mM EDTA, pH 7.2

Human TnT although stable at 10°C for 7 days, should be stored desiccated below -18°C.
Please prevent freeze-thaw cycles.

Small volumes of TNNT2 native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Description: Human Cardiac Troponin T produced from Human Cardiac Tissue, having a molecular weight of approximately 35 kDa.

The Cardiac troponin-T is purified using a combination of ion-exchange and affinity chromatography steps.

Introduction: Troponin-T is one of three subunits that form the troponin complex of the thin filaments of striated muscle, it regulates muscle contraction in response to alterations in intracellular calcium ion concentration. TnTc is expressed only in the heart and has proved to be a specific biomarker for heart disease. Mutations in TNNT2 are associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Alternative splicing results in many tissue-specific isoforms.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Cardiac Troponin

troponin T type 2 (cardiac)

troponin T, cardiac muscle; cardiomyopathy, dilated 1D (autosomal dominant); cardiomyopathy, hypertrophic 2; troponin T2, cardiac

Troponin T, cardiac muscle

TnTc; cTnT??[Similar Products]

TNNT2_HUMAN

The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq, Jul 2008]

TNNT2: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the ***** heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal ***** heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing ***** heart. Belongs to the troponin T family. 11 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Motor

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: sarcomere; troponin complex; cytosol; striated muscle thin filament

Molecular Function: troponin C binding; structural constituent of cytoskeleton; troponin I binding; ATPase activity; tropomyosin binding; actin binding

Biological Process: positive regulation of ATPase activity; regulation of muscle contraction; metabolic process; atrial cardiac muscle morphogenesis; ventricular cardiac muscle morphogenesis; sarcomere organization; response to calcium ion; negative regulation of ATPase activity; regulation of heart contraction; muscle filament sliding

Disease: Cardiomyopathy, Familial Restrictive, 3; Cardiomyopathy, Dilated, 1d; Cardiomyopathy, Familial Hypertrophic, 2

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