Full Product Name
Amylin Antibody
Product Synonym Names
Islet amyloid polypeptide [Precursor]; Amylin; Diabetes-associated peptide; DAP; Insulinoma amyloid peptide; IAPP
Product Gene Name
anti-IAPP antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P10997
Specificity
Amylin antibody detects endogenous levels of total amylin protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized peptide derived from human amylin(HQVEKRKC).
Preparation and Storage
Store at-20 degree C for 1 year
Other Notes
Small volumes of anti-IAPP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-IAPP antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-IAPP antibody
WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:10000
Immunohistochemistry (IHC) of anti-IAPP antibody
Peptide-+ Immunohistochemical analysis of paraffin-embedded human brain tissue using Amylin Antibody.
Western Blot (WB) of anti-IAPP antibody
Western blot analysis of extracts from HeLa cells, treated with EGF (200ng/ml, 30mins), using Amylin Antibody.
NCBI/Uniprot data below describe general gene information for IAPP. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000406.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000415.2
[Other Products]
UniProt Primary Accession #
P10997
[Other Products]
UniProt Secondary Accession #
Q0ZD87; Q14598[Other Products]
UniProt Related Accession #
P10997[Other Products]
Molecular Weight
9,806 Da[Similar Products]
NCBI Official Full Name
islet amyloid polypeptide preproprotein
NCBI Official Synonym Full Names
islet amyloid polypeptide
NCBI Official Symbol
IAPP??[Similar Products]
NCBI Official Synonym Symbols
DAP; IAP
??[Similar Products]
NCBI Protein Information
islet amyloid polypeptide
UniProt Protein Name
Islet amyloid polypeptide
UniProt Synonym Protein Names
Amylin; Diabetes-associated peptide; DAP; Insulinoma amyloid peptide
Protein Family
Islet amyloid polypeptide
UniProt Gene Name
IAPP??[Similar Products]
UniProt Synonym Gene Names
DAP??[Similar Products]
NCBI Summary for IAPP
This gene encodes a member of the calcitonin family of peptide hormones. This hormone is released from pancreatic beta cells following food intake to regulate blood glucose levels and act as a satiation signal. Human patients with type 1 and advanced type 2 diabetes exhibit reduced levels of the encoded hormone in blood and pancreas. This protein also exhibits a bactericidal, antimicrobial activity. [provided by RefSeq, Jul 2016]
UniProt Comments for IAPP
Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
Product References and Citations for anti-IAPP antibody
U Zimmermann, J. Endocrinol., Dec 1997; 155: 423-431. Peter J. Wookey, Hypertension, Sep 1997; 30: 455. M Alevizaki, Eur. J. Endocrinol., Nov 2001; 145: 585-589. Jack H. Jhamandas, J Neurophysiol, Jun 2003; 89: 2923.
Research Articles on IAPP
1. cholesterol significantly modulates the ability of model membranes to induce IAPP amyloid formation and IAPP-mediated membrane damage.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
