Endoribonuclease Dicer; Helicase with RNase motif; Helicase MOI; DICER1; DICER; HERNA; KIAA0928; 3.1.26.3

For Research Use Only. Not for use in diagnostic procedures.

Store at 4 degree C

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Small volumes of DICER1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9425264 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Endoribonuclease Dicer (DICER1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing DICER1. The ELISA analytical biochemical technique of the MBS9425264 kit is based on DICER1 antibody-DICER1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect DICER1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, DICER1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

92,726 Da

dicer 1, ribonuclease III

endoribonuclease Dicer

Endoribonuclease Dicer

DICER; HERNA; KIAA0928; Helicase MOI??[Similar Products]

This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]

DICER1: a cytoplasmic type-III RNase that plays a central role in RNA interference (RNAi) pathways to produce the active small RNAs that represses gene expression. Possesses a DEAD box RNA helicase motif in its amino terminus and a dsRNA-binding motif in the carboxy terminus. Dicer, along with Ago2 andTRBP, are the main components of the RNA-induced silencing complex (RISC). Fragile X syndrome repeats form RNA hairpins that are cut by Dicer but do not activate the interferon-inducible protein kinase, PKR. Four alternatively spliced isoforms have been described.

Protein type: Cell development/differentiation; EC 3.1.26.3; Helicase; RNA processing; RNA-binding; Ribonuclease

Chromosomal Location of Human Ortholog: 14q32.13

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: deoxyribonuclease I activity; double-stranded RNA binding; endoribonuclease activity; protein binding; protein domain specific binding; ribonuclease III activity; siRNA binding

Biological Process: DNA fragmentation during apoptosis; miRNA-mediated gene silencing, miRNA loading onto RISC; miRNA-mediated gene silencing, production of miRNAs; myelin formation in the peripheral nervous system; negative regulation of transcription from RNA polymerase II promoter; nerve development; neurite morphogenesis; positive regulation of myelination; positive regulation of Schwann cell differentiation; pre-microRNA processing; RNA interference, conversion of ds siRNA to ss siRNA; RNA interference, production of siRNA; RNA interference, siRNA loading onto RISC; RNA interference, targeting of mRNA for destruction

Disease: Goiter, Multinodular 1, With Or Without Sertoli-leydig Cell Tumors; Pleuropulmonary Blastoma; Rhabdomyosarcoma, Embryonal, 2

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