Product Name
Desmoplakin (DSP), Polyclonal Antibody
Full Product Name
Anti-Desmoplakin Antibody
Product Synonym Names
Desmoplakin; DP; 250/210 kDa paraneoplastic pemphigus antigen
Product Gene Name
anti-DSP antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P15924
Species Reactivity
Human, Mouse
Specificity
Recognizes endogenous levels of Desmoplakin protein.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Immunogen
KLH-conjugated synthetic peptide of human Desmoplakin
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-DSP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-DSP antibody
Rabbit polyclonal antibody to Desmoplakin
Applications Tested/Suitable for anti-DSP antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-DSP antibody
WB: 1/500 - 1/2000; IHC: 1/50 - 1/200
Western Blot (WB) of anti-DSP antibody
Western blot analysis of Desmoplakin expression in MCF7 (A), Hela (B), mouse heart (C) whole cell lysates.
Immunohistochemistry (IHC) of anti-DSP antibody
Immunohistochemical analysis of Desmoplakin staining in human stomach cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
NCBI/Uniprot data below describe general gene information for DSP. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001008844.1
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NCBI GenBank Nucleotide #
NM_001008844.2
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UniProt Primary Accession #
P15924
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UniProt Secondary Accession #
O75993; Q14189; Q9UHN4; B2RTT2; D7RX09[Other Products]
UniProt Related Accession #
P15924[Other Products]
Molecular Weight
278,916 Da
NCBI Official Full Name
desmoplakin isoform II
NCBI Official Synonym Full Names
desmoplakin
NCBI Official Symbol
DSP??[Similar Products]
NCBI Official Synonym Symbols
DP; DCWHKTA
??[Similar Products]
NCBI Protein Information
desmoplakin
UniProt Protein Name
Desmoplakin
UniProt Synonym Protein Names
250/210 kDa paraneoplastic pemphigus antigen
Protein Family
Desmoplakin
UniProt Gene Name
DSP??[Similar Products]
UniProt Synonym Gene Names
DP??[Similar Products]
UniProt Entry Name
DESP_HUMAN
NCBI Summary for DSP
This gene encodes a protein that anchors intermediate filaments to desmosomal plaques and forms an obligate component of functional desmosomes. Mutations in this gene are the cause of several cardiomyopathies and keratodermas, including skin fragility-woolly hair syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
UniProt Comments for DSP
Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes.
Research Articles on DSP
1. novel de novo heterozygous missense mutation caused severe dermatitis, multiple allergies, and metabolic wasting syndrome
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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