Full Product Name
ROBO3 Antibody
Product Gene Name
anti-ROBO3 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q96MS0
Other Notes
Small volumes of anti-ROBO3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ROBO3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_071765.2
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NCBI GenBank Nucleotide #
NM_022370.3
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UniProt Primary Accession #
Q96MS0
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UniProt Related Accession #
Q96MS0[Other Products]
Molecular Weight
110,676 Da
NCBI Official Full Name
roundabout homolog 3
NCBI Official Synonym Full Names
roundabout guidance receptor 3
NCBI Official Symbol
ROBO3??[Similar Products]
NCBI Official Synonym Symbols
HGPS; RIG1; HGPPS; RBIG1; HGPPS1
??[Similar Products]
NCBI Protein Information
roundabout homolog 3
UniProt Protein Name
Roundabout homolog 3
UniProt Synonym Protein Names
Roundabout-like protein 3
Protein Family
Roundabout
UniProt Gene Name
ROBO3??[Similar Products]
NCBI Summary for ROBO3
This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS); an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. Alternative transcript variants have been described but have not been experimentally validated. [provided by RefSeq, Dec 2009]
UniProt Comments for ROBO3
Thought to be involved during neural development in axonal navigation at the ventral midline of the neural tube. In spinal chord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1 (). Required for hindbrain axon midline crossing.
Research Articles on ROBO3
1. T) causing a premature stop codon which is a disease-making mutation.">In our case, we found a novel homozygous mutation p.R842* (c.2524C>T) causing a premature stop codon which is a disease-making mutation.
Precautions
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