Full Product Name
FAT4 Antibody
Product Synonym Names
FATJ; FAT-J; CDHF14; CDHR11; NBLA00548
Product Gene Name
anti-FAT4 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q6V0I7
Specificity
The antibody detects endogenous levels of total FAT4 protein.
Purity/Purification
Antigen affinity purification.
Form/Format
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Concentration
0.7 mg/ml (lot specific)
Immunogen Description
Synthetic peptide corresponding to residues near the C terminal of human FAT tumor suppressor homolog 4 (Drosophila)
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-FAT4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-FAT4 antibody
FAT1, FAT2, FAT3 and FAT4 are human homologs of Drosophila Fat, which is involved in tumor suppression and planar cell polarity (PCP). FAT4 undergo the first proteolytic cleavage by Furin and are predicted to undergo the second cleavage by g secretase to release intracellular domain (ICD). FAT4 directly interacts with MPDZ/MUPP1 to recruit membrane associated guanylate kinase MPP5/PALS1. FAT4 is involved in the maintenance of PCP and inhibition of cell proliferation.
Product Categories/Family for anti-FAT4 antibody
Total protein Ab
Applications Tested/Suitable for anti-FAT4 antibody
Immunohistochemistry (IHC)
Application Notes for anti-FAT4 antibody
Immunohistochemistry: 1:25-1:100
Immunohistochemistry (IHC) of anti-FAT4 antibody
Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using at dilution 1/20.
Immunohistochemistry (IHC) of anti-FAT4 antibody
Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using at dilution 1/20.
NCBI/Uniprot data below describe general gene information for FAT4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001278214.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001291285.1
[Other Products]
UniProt Primary Accession #
Q6V0I7
[Other Products]
UniProt Secondary Accession #
Q3LIA6; Q8TCK7; Q9H5T6; A8K5Z6; B5MDG4[Other Products]
UniProt Related Accession #
Q6V0I7[Other Products]
Molecular Weight
542,616 Da
NCBI Official Full Name
protocadherin Fat 4 isoform 2
NCBI Official Synonym Full Names
FAT atypical cadherin 4
NCBI Official Symbol
FAT4??[Similar Products]
NCBI Official Synonym Symbols
FATJ; FAT-J; CDHF14; CDHR11; HKLLS2; VMLDS2; NBLA00548
??[Similar Products]
NCBI Protein Information
protocadherin Fat 4
UniProt Protein Name
Protocadherin Fat 4
UniProt Synonym Protein Names
Cadherin family member 14; FAT tumor suppressor homolog 4; Fat-like cadherin protein FAT-J
Protein Family
Protocadherin
UniProt Gene Name
FAT4??[Similar Products]
UniProt Synonym Gene Names
CDHF14; FATJ; hFat4??[Similar Products]
UniProt Entry Name
FAT4_HUMAN
NCBI Summary for FAT4
The protein encoded by this gene is a member of the protocadherin family. This gene may play a role in regulating planar cell polarity (PCP). Studies in mice suggest that loss of PCP signaling may cause cystic kidney disease, and mutations in this gene have been associated with Van Maldergem Syndrome 2. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Mar 2014]
UniProt Comments for FAT4
FAT4: May function in the regulation of planar cell polarity. Cadherins are cell-cell interaction molecules. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Cell adhesion
Chromosomal Location of Human Ortholog: 4q28.1
Cellular Component: apical part of cell; integral to membrane; plasma membrane
Molecular Function: protein binding; calcium ion binding
Biological Process: heterophilic cell adhesion; heart morphogenesis; inner ear receptor stereocilium organization and biogenesis; gut development; plasma membrane organization and biogenesis; neurogenesis; ureteric bud branching; cerebral cortex development; homophilic cell adhesion
Disease: Van Maldergem Syndrome 2; Hennekam Lymphangiectasia-lymphedema Syndrome 2
Research Articles on FAT4
1. These findings suggest that Fat and Dachsous self-bend due to the loss of Ca(2+)-binding amino acids from specific EC-EC linkers, and can therefore adapt to confined spaces.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
