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Desmoplakin 1 + 2, Monoclonal Antibody

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產(chǎn)品名稱: Desmoplakin 1 + 2, Monoclonal Antibody
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Desmoplakin 1 + 2, Monoclonal Antibody


Desmoplakin 1 + 2, Monoclonal Antibody  的詳細(xì)介紹
Product Name

Desmoplakin 1 + 2 (DSP), Monoclonal Antibody

Popular Item
Full Product Name

Desmoplakin 1 + 2 antibody

Product Synonym Names
Monoclonal Desmoplakin 1 + 2; Anti-Desmoplakin 1 + 2; Desmoplakin 1/2
Product Gene Name

anti-DSP antibody

[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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OMIM
125647
3D Structure
ModBase 3D Structure for P15924
Clonality
Monoclonal
Isotype
IgG1
Clone Number
DP-2.15 + DP-2.17 + DP-2.20
Host
Mouse
Species Reactivity
Bovine, Chicken, Dog, Human, Mouse and Rat.
Several human CA lines: MCF-7, 431; rat MH1C1 cell line; bovine cells: BMGE, MDBK.
Specificity
Bovine desmoplakin 1/2
Purity/Purification
Culture supernatant
Form/Format
Supplied as a liquid, contains 0.09% Sodium Azide
Concentration
5ml per vial (lot specific)
Biological Significance
Desmoplakin is a protein associated with desmosomes. Desmoplakin is a protein that in humans is encoded by the DSP gene. Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin.
Biohazard Information
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
Immunogen
Desmoplakin 1/2 antibody was raised in mouse using bovine desmoplakin 1 and 2 as the immunogen.
Preparation and Storage
Store at 4 degree C.
Other Notes
Small volumes of anti-DSP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for
anti-DSP antibody
Mouse monoclonal Desmoplakin 1 + 2 antibody
Product Categories/Family for anti-DSP antibody
Cell Biology
Applications Tested/Suitable for anti-DSP antibody
Immunohistochemistry (IHC) Formalin/Paraffin, Western Blot (WB)
Application Notes for anti-DSP antibody
Suitable use for, Immunohistochemistry 1:10, frozen tissue immunoblotting (Western) and paraffin sections (using antigen release methods/microwave), and Cytological material. Contains clones: DP1&2-2.15, DP1-2.17, DP1&2-2.20

Optimal conditions to be determined by end use.
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NCBI/Uniprot data below describe general gene information for DSP. It may not necessarily be applicable to this product.
NCBI GI #
58530840
NCBI GeneID
1832
NCBI Accession #
NP_004406.2 [Other Products]
NCBI GenBank Nucleotide #
NM_004415.2 [Other Products]
UniProt Primary Accession #
P15924 [Other Products]
UniProt Secondary Accession #
O75993; Q14189; Q9UHN4; B2RTT2; D7RX09[Other Products]
UniProt Related Accession #
P15924[Other Products]
Molecular Weight
278,916 Da[Similar Products]
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NCBI Official Full Name
desmoplakin isoform I
NCBI Official Synonym Full Names
desmoplakin
NCBI Official Symbol
DSP??[Similar Products]
NCBI Official Synonym Symbols
DP; DPI; DPII; DCWHKTA
??[Similar Products]
NCBI Protein Information
desmoplakin
UniProt Protein Name
Desmoplakin
UniProt Synonym Protein Names
250/210 kDa paraneoplastic pemphigus antigen
Protein Family
Desmoplakin
UniProt Gene Name
DSP??[Similar Products]
UniProt Synonym Gene Names
DP??[Similar Products]
UniProt Entry Name
DESP_HUMAN
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NCBI Summary for DSP
Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus. [provided by RefSeq, Jul 2008]
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UniProt Comments for DSP
Desmoplakin: Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes. Homodimer. Interacts with COL17A1 (via cytoplasmic region). Associates (via C-terminal) with KRT5-KRT14 (via rod region), KRT8-KRT18 and VIM intermediate filaments. Interacts with DSC2. Isoform DPI is apparently an obligate constituent of all desmosomes. Isoform DPII resides predominantly in tissues and cells of stratified origin. Belongs to the plakin or cytolinker family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal; Cell adhesion

Chromosomal Location of Human Ortholog: 6p24

Cellular Component: desmosome; mitochondrion; basolateral plasma membrane; plasma membrane; intermediate filament; cornified envelope; fascia adherens; nucleus

Molecular Function: protein binding, bridging; protein binding; protein kinase C binding; structural constituent of cytoskeleton; cell adhesion molecule binding; structural molecule activity

Biological Process: keratinocyte differentiation; cell-cell adhesion; epidermis development; wound healing; apoptosis; intermediate filament organization; peptide cross-linking; cell structure disassembly during apoptosis

Disease: Cardiomyopathy, Dilated, With Woolly Hair And Keratoderma; Arrhythmogenic Right Ventricular Dysplasia, Familial, 8; Keratosis Palmoplantaris Striata Ii; Cardiomyopathy, Dilated, With Woolly Hair, Keratoderma, And Tooth Agenesis; Skin Fragility-woolly Hair Syndrome; Epidermolysis Bullosa, Lethal Acantholytic
Research Articles on DSP
1. Case Report: PKP2/DSP mutations in patient with Brugada syndrome and ventricular tachycardia.
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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