Product Name
TIRAP, Blocking Peptide
Full Product Name
TIRAP Peptide - middle region
Product Gene Name
TIRAP blocking peptide
[Similar Products]
Product Synonym Gene Name
FLJ42305; Mal; wyatt; BACTS1[Similar Products]
TIRAP peptide (MBS3235975) is used for blocking the activity of TIRAP antibody (MBS3211022)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q56UH9
Form/Format
Lyophilized powder
Preparation and Storage
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.
Other Notes
Small volumes of TIRAP blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
TIRAP blocking peptide
This is a synthetic peptide designed for use in combination with anti-TIRAP antibody made
Target Description: The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleuk
Product Categories/Family for TIRAP blocking peptide
Peptide
Applications Tested/Suitable for TIRAP blocking peptide
Western Blot (WB)
NCBI/Uniprot data below describe general gene information for TIRAP. It may not necessarily be applicable to this product.
NCBI Accession #
NP_683708
[Other Products]
NCBI GenBank Nucleotide #
NM_148910
[Other Products]
UniProt Primary Accession #
Q56UH9
[Other Products]
UniProt Related Accession #
P58753[Other Products]
NCBI Official Full Name
toll/interleukin-1 receptor domain-containing adapter protein isoform b
NCBI Official Synonym Full Names
TIR domain containing adaptor protein
NCBI Official Symbol
TIRAP??[Similar Products]
NCBI Official Synonym Symbols
Mal; wyatt; BACTS1; MyD88-2
??[Similar Products]
NCBI Protein Information
toll/interleukin-1 receptor domain-containing adapter protein
Protein Family
Toll/interleukin-1 receptor domain-containing adapter protein
NCBI Summary for TIRAP
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
Research Articles on TIRAP
1. TIRAP is phosphorylated at Thr28 within its phosphoinositide (PI)-binding motif (PBM), which leads to its ubiquitination and degradation. The authors demonstrate that phosphorylation distorts the helical structure of TIRAP PBM, reducing PI interactions and cell membrane targeting.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
