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TIRAP, Polyclonal Antibody

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產(chǎn)品名稱: TIRAP, Polyclonal Antibody
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TIRAP, Polyclonal Antibody


TIRAP, Polyclonal Antibody  的詳細(xì)介紹
Product Name

TIRAP, Polyclonal Antibody

Popular Item
Full Product Name

TIRAP Antibody

Product Gene Name

anti-TIRAP antibody

[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Immunogen Type
Peptide
Immunogen Description
Raised against a peptide corresponding to 15 amino acids near the C-terminus of mouse TIRAP.
Target Name
TIRAP
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Other Notes
Small volumes of anti-TIRAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for
anti-TIRAP antibody
Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as TIRAP and MyD88 to activate various kinases and transcription factors. In TIRAP-deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 and TLR6 as co-receptors) is totally abolished, suggesting that MyD88 and TIRAP work together and are both required for TLR2 signaling. Furthermore, these mice are also resistant to the toxic effects of LPS and show defects in NF- B and MAP kinase activation, suggesting that TIRAP is also involed in TLR4 signaling.
Product Categories/Family for anti-TIRAP antibody
Total protein Ab
Applications Tested/Suitable for anti-TIRAP antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Western Blot (WB) of anti-TIRAP antibody
Western blot analysis of TIRAP in human heart cell lysates with TIRAP antibody at (A) 0.5, (B) 1, and (C) 2 ug/mL.
anti-TIRAP antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-TIRAP antibody
Immunohistochemical staining of human heart cells using TIRAP antibody at 2 ug/mL.
anti-TIRAP antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for TIRAP. It may not necessarily be applicable to this product.
NCBI GI #
15705409
NCBI GeneID
117149
NCBI Accession #
AAL05628 [Other Products]
UniProt Secondary Accession #
Q91ZW0[Other Products]
UniProt Related Accession #
Q99JY1[Other Products]
Molecular Weight
26,035 Da
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NCBI Official Full Name
TIR domain containing adaptor protein TIRAP
NCBI Official Synonym Full Names
toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
NCBI Official Symbol
Tirap??[Similar Products]
NCBI Official Synonym Symbols
Mal; Wyatt; Tlr4ap; AA407980; C130027E04Rik
??[Similar Products]
NCBI Protein Information
toll/interleukin-1 receptor domain-containing adapter protein
UniProt Protein Name
Toll/interleukin-1 receptor domain-containing adapter protein
UniProt Synonym Protein Names
Adaptor protein Wyatt; MyD88 adapter-like protein
Protein Family
Toll/interleukin-1 receptor domain-containing adapter protein
UniProt Gene Name
Tirap??[Similar Products]
UniProt Synonym Gene Names
Mal; TIR domain-containing adapter protein??[Similar Products]
UniProt Entry Name
TIRAP_MOUSE
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UniProt Comments for TIRAP
TIRAP: an adapter protein involved in the TLR4 signaling pathway in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, ERK1, ERK2 and JNK, resulting in cytokine secretion and the inflammatory response. Homodimerizes. Also forms heterodimers with MyD88. Binds to TLR4 and IRAK2 via their respective TIR domains. Binds to PKR and TBK1. Does not interact with IRAK1, nor TLR9. Genetic variations in TIRAP can influence susceptibility or resistance to infectious diseases, including invasive pneumococcal disease, malaria and tuberculosis. Three isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Cellular Component: nucleoplasm; intercellular bridge; membrane; endocytic vesicle; cytoplasm; plasma membrane; peroxisome; intracellular

Molecular Function: protein binding; phosphatidylinositol-4,5-bisphosphate binding; protein homodimerization activity; protein kinase C binding; protein heterodimerization activity

Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-12 production; positive regulation of interleukin-6 biosynthetic process; positive regulation of JNK cascade; response to lipopolysaccharide; signal transduction; activation of JNK activity; activation of NF-kappaB transcription factor; positive regulation of interleukin-8 production; toll-like receptor 5 signaling pathway; cell surface receptor linked signal transduction; positive regulation of interleukin-15 production; positive regulation of innate immune response; positive regulation of B cell proliferation; inflammatory response; positive regulation of toll-like receptor 3 signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; immune system process; positive regulation of toll-like receptor 4 signaling pathway; regulation of interleukin-15 production; positive regulation of tumor necrosis factor production; positive regulation of toll-like receptor 2 signaling pathway; regulation of innate immune response; defense response to Gram-positive bacterium; response to bacterium; innate immune response; myeloid cell differentiation; regulation of interferon-beta production
Research Articles on TIRAP
1. MyD88 adaptor-like (Mal) functions in the epithelial barrier and contributes to intestinal integrity via protein kinase C.
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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