Rabbit Polyclonal (IgG) to Human CYP27/CYP27A1; CYP27A1; Cytochrome P450 27; CTX; Cytochrome P-450C27/25; CP27; Vitamin D(3) 25-hydroxylase; CYP27; Sterol 27-hydroxylase

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Cytochrome P450 27A1 Antibody detects endogenous levels of total Cytochrome P450 27A1 protein.

Immunoaffinity Purified

PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol

Store at -20 degree C for up to one year.

Small volumes of anti-CYP27/CYP27A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

CYP27/CYP27A1 is a member of the cytochrome P450 superfamily ofenzymes. the cytochrome P450 proteins are monooxygenases which catalyzemany reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein oxidizescholesterol intermediates as part of the bile synthesis pathway.

Cytochrome P450

ELISA (EIA), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)

ELISA: 1:10000
IHC-P: 1:50
WB: 1:500-1:1000

Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)

Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

Western blot of extracts from HeLa cells, using Cytochrome P450 27A1 Antibody. The lane on the right is treated with the synthesized peptide.

60,235 Da

cytochrome P450 family 27 subfamily A member 1

sterol 26-hydroxylase, mitochondrial

Sterol 26-hydroxylase, mitochondrial

CYP27??[Similar Products]

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein oxidizes cholesterol intermediates as part of the bile synthesis pathway. Since the conversion of cholesterol to bile acids is the major route for removing cholesterol from the body, this protein is important for overall cholesterol homeostasis. Mutations in this gene cause cerebrotendinous xanthomatosis, a rare autosomal recessive lipid storage disease. [provided by RefSeq, Jul 2008]

Catalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol. Has also a vitamin D3-25-hydroxylase activity.

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