Anti -TRPM6, ID (Transient Receptor Potential Cation Channel Subfamily M Member 6, Channel-kinase 2, Melastatin-related TRP Cation Channel 6, CHAK2)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 9; NC_000009.11 (77337411..77503010, complement). Location: 9q21.13

Polyclonal

IgG

Rabbit

Recognizes human CHAK2.

Affinity Purified
Purified by Protein G affinity chromatography.

Supplied as a liquid in PBS, 0.09% sodium azide.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-TRPM6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

CHAK2 is a member of the ion channel proteins. It regulates the calcium concentration in cells, which is imperative for such functions as muscle contractions and neuronal firing. It is also upregulated in certain forms of cancer and could play a role in diabetes.

Antibodies; Abs to Ion Channel

ELISA (EL/EIA), Immunohistochemistry (IHC)

Suitable for use in ELISA and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Immunohistochemistry: 1:50-1:100

131,263 Da[Similar Products]

transient receptor potential cation channel, subfamily M, member 6

transient receptor potential cation channel subfamily M member 6; channel kinase 2; OTTHUMP00000021487; melastatin-related TRP cation channel 6

Transient receptor potential cation channel, subfamily M, member 6

Q5VYG5_HUMAN

This gene is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. It is crucial for magnesium homeostasis, and plays an essential role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Mutations in this gene are associated with hypomagnesemia with secondary hypocalcemia. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq]

ChaK2: is an unusual bifunctional protein containing a transient receptor potential (TRP) ion channel fused to a protein kinase of the Atypical alpha group. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. ChaK2 mutations cause hereditary hypomagnesemia and secondary hypocalcemia (HSH). The TRP voltage-independent calcium-permeable cation channels are divided into six subfa milies, two of which (TRPC and TRPM) have members that are widely expressed and activated by oxidative stress. Related to ChaK1, another Atypical alpha kinase fused to a TRP ion channel protein. Forms homodimers or heterodimers with ChaK1. Six alternatively spliced isoforms have been described, three of which lack the ion channel region.

Protein type: Protein kinase, atypical; Channel, cation; Membrane protein, integral; Kinase, protein; Membrane protein, multi-pass; EC 2.7.11.1; ATYPICAL group; Alpha family; ChaK subfamily

Chromosomal Location of Human Ortholog: 9q21.13

Cellular Component: brush border membrane; apical plasma membrane; integral to membrane; plasma membrane

Molecular Function: protein serine/threonine kinase activity; protein binding; metal ion binding; calcium channel activity; ATP binding

Biological Process: response to toxin; transmembrane transport; protein amino acid phosphorylation

Disease: Hypomagnesemia 1, Intestinal

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