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TRPM6 (CHAK2), Blocking Peptide

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產品名稱: TRPM6 (CHAK2), Blocking Peptide
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TRPM6 (CHAK2), Blocking Peptide


TRPM6 (CHAK2), Blocking Peptide  的詳細介紹
Product Name

TRPM6 (CHAK2), Blocking Peptide

Full Product Name

TRPM6 (CHAK2) Antibody (Center) Blocking peptide

Product Synonym Names
Transient receptor potential cation channel subfamily M member 6; Channel kinase 2; Melastatin-related TRP cation channel 6; TRPM6; CHAK2
Product Gene Name

TRPM6 blocking peptide

[Similar Products]
Product Synonym Gene Name
CHAK2[Similar Products]
Antibody/Peptide Pairs
TRPM6 (CHAK2) peptide (MBS9227495) is used for blocking the activity of TRPM6 (CHAK2) antibody (MBS9202719)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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OMIM
602014
3D Structure
ModBase 3D Structure for Q9BX84
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the Center region of human CHAK2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Form/Format
The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
Cellular Location
Cell membrane; Multi-pass membrane protein
Tissue Location
Highly expressed in kidney and colon. Isoform TRPM6a and isoform TRPM6b, are coexpressed with TRPM7 in kidney, and testis, and are also found in several cell lines of lung origin. Isoform TRPM6c is detected only in testis and in NCI-H510A small cell lung carcinoma cells
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of TRPM6 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for
TRPM6 blocking peptide
Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region.
NCBI/Uniprot data below describe general gene information for TRPM6. It may not necessarily be applicable to this product.
NCBI GI #
56404951
NCBI GeneID
140803
NCBI Accession #
Q9BX84.2 [Other Products]
UniProt Primary Accession #
Q9BX84 [Other Products]
UniProt Secondary Accession #
Q6VPR8; Q6VPR9; Q6VPS0; Q6VPS1; Q6VPS2[Other Products]
UniProt Related Accession #
Q9BX84[Other Products]
Molecular Weight
65,083 Da
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NCBI Official Full Name
Transient receptor potential cation channel subfamily M member 6
NCBI Official Synonym Full Names
transient receptor potential cation channel subfamily M member 6
NCBI Official Symbol
TRPM6??[Similar Products]
NCBI Official Synonym Symbols
HSH; HMGX; HOMG; CHAK2; HOMG1
??[Similar Products]
NCBI Protein Information
transient receptor potential cation channel subfamily M member 6
UniProt Protein Name
Transient receptor potential cation channel subfamily M member 6
UniProt Synonym Protein Names
Channel kinase 2; Melastatin-related TRP cation channel 6
Protein Family
Transient receptor potential cation channel subfamily
UniProt Gene Name
TRPM6??[Similar Products]
UniProt Synonym Gene Names
CHAK2??[Similar Products]
UniProt Entry Name
TRPM6_HUMAN
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NCBI Summary for TRPM6
This gene is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. It is crucial for magnesium homeostasis, and plays an essential role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Mutations in this gene are associated with hypomagnesemia with secondary hypocalcemia. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Apr 2010]
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UniProt Comments for TRPM6
ChaK2: is an unusual bifunctional protein containing a transient receptor potential (TRP) ion channel fused to a protein kinase of the Atypical alpha group. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. ChaK2 mutations cause hereditary hypomagnesemia and secondary hypocalcemia (HSH). The TRP voltage-independent calcium-permeable cation channels are divided into six subfa milies, two of which (TRPC and TRPM) have members that are widely expressed and activated by oxidative stress. Related to ChaK1, another Atypical alpha kinase fused to a TRP ion channel protein. Forms homodimers or heterodimers with ChaK1. Six alternatively spliced isoforms have been described, three of which lack the ion channel region.

Protein type: Kinase, protein; EC 2.7.11.1; Membrane protein, integral; Membrane protein, multi-pass; Channel, cation; Protein kinase, atypical; ATYPICAL group; Alpha family; ChaK subfamily

Chromosomal Location of Human Ortholog: 9q21.13

Cellular Component: plasma membrane

Molecular Function: calcium channel activity; protein binding

Biological Process: response to toxin

Disease: Hypomagnesemia 1, Intestinal
Research Articles on TRPM6
1. The Different Roles of The Channel-Kinases TRPM6 and TRPM7
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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