Full Product Name
TIRAP Antibody
Product Synonym Names
Adaptor protein Wyatt; MAL; MyD88 adapter-like protein; TIR domain-containing adapter protein; Toll-interleukin 1 receptor domain-containing adapter protein
Product Gene Name
anti-TIRAP antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P58753
Species Reactivity
Human, Mouse
Specificity
TIRAP Antibody detects endogenous levels of TIRAP.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Unmodified/Total
Immunogen
The antiserum was produced against synthesized peptide derived from human TIRAP.
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Other Notes
Small volumes of anti-TIRAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-TIRAP antibody
Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-TIRAP antibody
IHC: 1:50~1:100
ELISA: 1:10000
NCBI/Uniprot data below describe general gene information for TIRAP. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001034750.1
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NCBI GenBank Nucleotide #
NM_001039661.1
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UniProt Primary Accession #
P58753
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UniProt Secondary Accession #
Q56UH9; Q56UI0; Q8N5E5; B3KW65[Other Products]
UniProt Related Accession #
P58753[Other Products]
NCBI Official Full Name
toll/interleukin-1 receptor domain-containing adapter protein isoform a
NCBI Official Synonym Full Names
TIR domain containing adaptor protein
NCBI Official Symbol
TIRAP??[Similar Products]
NCBI Official Synonym Symbols
Mal; wyatt; BACTS1; MyD88-2
??[Similar Products]
NCBI Protein Information
toll/interleukin-1 receptor domain-containing adapter protein
UniProt Protein Name
Toll/interleukin-1 receptor domain-containing adapter protein
UniProt Synonym Protein Names
Adaptor protein Wyatt; MyD88 adapter-like protein; MyD88-2
Protein Family
Toll/interleukin-1 receptor domain-containing adapter protein
UniProt Gene Name
TIRAP??[Similar Products]
UniProt Synonym Gene Names
MAL; TIR domain-containing adapter protein; MyD88-2??[Similar Products]
NCBI Summary for TIRAP
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
UniProt Comments for TIRAP
Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.
Research Articles on TIRAP
1. Combined targeting of UBAP1 and toll-like receptor adaptors TIRAP and MyD88 by Pseudomonas aeruginosa PumA impedes both cytokine and toll-like receptor signalling, highlighting a novel strategy for innate immune evasion.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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