Product Name
Consortin (CNST), Recombinant Protein
Full Product Name
Recombinant Human Consortin (CNST)
Product Gene Name
CNST recombinant protein
[Similar Products]
Product Synonym Gene Name
C1orf71[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-725aa; full length protein
Sequence
MDDSDTPTYY LQIEPQDGCH PGDSVERSVT CLPSASDENE NQLDGDGHEH LTSSDSAMGK PQVSEQDSLN NNESCTLSCE VAAGENLQNT LCEASRDEQA FLGKDKKIPG KRSPRSKKGT AKKIPPGLFS GDIAPLMQEK VLSAVTYAVD DEEAAEVNAN EQPEAPKLVL QSLFSLIRGE VEQLDSRALP LCLHQIAESY FQEEDYEKAM KFIQLERLYH EQLLANLSAI QEQWETKWKT VQPHTVTALR NSEKGFNGED FERLTKICAT HQDPLLSKHK IAAVEKSQER KCSTQLLVSE DPKEGGATTK ESESKTCLGT ESSKESQHTV EPLGSSPCCH QMDVQTDSPS LSVTAGKDHM EELLCSAEAT LALHTQSSET AGSPSGPDSS EDACEDDSRL QLAQTEACQD VARIEGIAED PKVFLSSKSK TEPLISPGCD RIPPALISEG KYSQAQRKEL RLPLRDASEA LPTDQLENNE LNELQQPDLT DSDGKSPQAQ ADSDGSENVL CGNNQISDLG ILLPEVCMAP EEKGDKDDQL NKETEDYLNS LLEGCLKDTE DSLSYEDNQD DDSDLLQDLS PEEASYSLQE NLPSDESCLS LDDLAKRIEI AEVVPTEGLV SILKKRNDTV GDHPAQMQHK PSKRRVRFQE IDDSLDQDEV GGGSCILLVL LCIATVFLSV GGTALYCTFG DMESPVCTDF ADNMDFYYTK LLQGVAELKH WIYLS
3D Structure
ModBase 3D Structure for Q6PJW8
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Storage Buffer
Tris-based buffer, 50% glycerol.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CNST recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for CNST recombinant protein
Transmembrane Protein
Application Notes for CNST recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
NCBI/Uniprot data below describe general gene information for CNST. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001132931.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001139459.1
[Other Products]
UniProt Primary Accession #
Q6PJW8
[Other Products]
UniProt Secondary Accession #
Q5VSY9; Q5VTM7; Q8IYA9; Q8N3L5; Q8NB09; Q8TEI2; Q96MR5[Other Products]
UniProt Related Accession #
Q6PJW8[Other Products]
Molecular Weight
29,306 Da
NCBI Official Full Name
consortin isoform 2
NCBI Official Synonym Full Names
consortin, connexin sorting protein
NCBI Official Symbol
CNST??[Similar Products]
NCBI Official Synonym Symbols
C1orf71; PPP1R64
??[Similar Products]
NCBI Protein Information
consortin
UniProt Protein Name
Consortin
UniProt Gene Name
CNST??[Similar Products]
UniProt Synonym Gene Names
C1orf71??[Similar Products]
UniProt Entry Name
CNST_HUMAN
NCBI Summary for CNST
Targeting of numerous transmembrane proteins to the cell surface is thought to depend on their recognition by cargo receptors that interact with the adaptor machinery for anterograde traffic at the distal end of the Golgi complex. Consortin (CNST) is an integral membrane protein that acts as a binding partner of connexins, the building blocks of gap junctions, and acts as a trans-Golgi network (TGN) receptor involved in connexin targeting to the plasma membrane and recycling from the cell surface (del Castillo et al., 2010 [PubMed 19864490]).[supplied by OMIM, Jun 2010]
UniProt Comments for CNST
CNST: Required for targeting of connexins to the plasma membrane. Belongs to the CNST family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 1q44
Cellular Component: integral to membrane; membrane; plasma membrane; protein complex; trans-Golgi network; transport vesicle
Molecular Function: phosphatase binding; protein binding
Biological Process: positive regulation of Golgi to plasma membrane protein transport
Research Articles on CNST
1. Consortin is a trans-Golgi network cargo receptor for the plasma membrane targeting and recycling of connexins.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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