Mouse Gamma-aminobutyric acid type B receptor subunit 1 (GABBR1) ELISA kit; DAAP-188P13.3; FLJ92613; GABABR1; GABBR1-3; GB1; GPRC3A; dJ271M21.1.1; dJ271M21.1.2; GABA-B receptor; GABAB; subunit 1c; OTTHUMP00000109099; gamma-aminobutyric acid (GABA) B receptor 1; gamma-aminobutyr; gamma-aminobutyric acid (GABA) B receptor; 1

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of GABBR1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9332091 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the gamma-aminobutyric acid (GABA) B receptor, 1 (GABBR1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing GABBR1. The ELISA analytical biochemical technique of the MBS9332091 kit is based on GABBR1 antibody-GABBR1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GABBR1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GABBR1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

108,216 Da

gamma-aminobutyric acid (GABA) B receptor, 1

gamma-aminobutyric acid type B receptor subunit 1; gb1; GABA-BR1; GABA-B-R1; GABA-B receptor 1; GABA-BR1b receptor; gamma-aminobutyric acid (GABA-B) receptor, 1; bM573K1.1.1 (gamma-aminobutyric acid (GABA) B receptor, 1a)

Gamma-aminobutyric acid type B receptor subunit 1

GABA-B receptor 1; GABA-B-R1; GABA-BR1; GABABR1; Gb1??[Similar Products]

GABR1_MOUSE

GABBR1: Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high- voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Activated by (-)-baclofen, cgp27492 and blocked by phaclofen. Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Isoform 1E (without C-terminal intracellular domain) is unable to dimerize via a coiled-coil interaction with GABA-B-R2. Interacts with the leucine zipper of the C-terminal bZIP domain of ATF4 via its C-terminal region. Interacts with JAKMIP1. Highly expressed in brain and weakly in heart, small intestine and uterus. Isoform 1A is mostly expressed in granular cell and molecular layer. Isoform 1B is mostly expressed in Purkinje cells. Isoform 1E is predominantly expressed in peripheral tissues as kidney, lung, trachea, colon, small intestine, stomach, bone marrow, thymus and mammary gland. Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; GPCR, family 3; Receptor, GPCR; Membrane protein, integral

Cellular Component: extracellular space; endoplasmic reticulum membrane; neuron projection; intracellular membrane-bound organelle; integral to plasma membrane; dendritic spine; integral to membrane; axolemma; lipid raft; presynaptic membrane; postsynaptic membrane; synaptic vesicle; cell projection; membrane; cell soma; cytoplasm; mitochondrial membrane; plasma membrane; synapse; dendritic shaft; cell junction

Molecular Function: G-protein coupled receptor activity; protein binding; signal transducer activity; GABA-B receptor activity; transcription factor binding

Biological Process: regulation of glutamate secretion; negative regulation of adenylate cyclase activity; negative regulation of gamma-aminobutyric acid secretion; positive regulation of glutamate secretion; signal transduction; negative regulation of synaptic transmission; osteoblast differentiation; positive regulation of growth hormone secretion; G-protein coupled receptor protein signaling pathway; negative regulation of cell proliferation; negative regulation of epinephrine secretion; G-protein signaling, adenylate cyclase inhibiting pathway; regulation of cAMP biosynthetic process; negative regulation of dopamine secretion; gamma-aminobutyric acid signaling pathway

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