Probable cation-transporting ATPase 13A2; 363-; ATP13A2; PARK9

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This ATP13A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1133-1161 amino acids from the C-terminal region of human ATP13A2.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.5 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-ATP13A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes a member of the P5 subfamily of ATPases
which transports inorganic cations as well as other substrates.
Mutations in this gene are associated with Kufor-Rakeb syndrome
(KRS), also referred to as Parkinson disease 9. Multiple transcript
variants encoding different isoforms have been found for this gene.

Metabolism; Neuroscience; Signal Transduction

Western Blot (WB), ELISA (EIA)

WB~~1:1000

ATP13A2 Antibody (C-term) western blot analysis in U251 cell line lysates (35ug/lane).This demonstrates the ATP13A2 antibody detected the ATP13A2 protein (arrow).

128794

ATPase type 13A2

probable cation-transporting ATPase 13A2

Probable cation-transporting ATPase 13A2

PARK9??[Similar Products]

AT132_HUMAN

This gene encodes a member of the P5 subfamily of ATPases which transports inorganic cations as well as other substrates. Mutations in this gene are associated with Kufor-Rakeb syndrome (KRS), also referred to as Parkinson disease 9. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2008]

ATP13A2: May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity. Expressed in brain; protein levels are markedly increased in brain from subjects with Parkinson disease and subjects with dementia with Lewy bodies. Detected in pyramidal neurons located throughout the cingulate cortex. In the substantia nigra, it is found in neuromelanin- positive dopaminergic neurons. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter, ion channel; Transporter; Hydrolase; Membrane protein, multi-pass; Membrane protein, integral; EC 3.6.3.-

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: lysosomal membrane; lysosome; integral to membrane

Molecular Function: protein binding; metal ion binding; ATPase activity; ATP binding

Biological Process: metabolic process; cation transport

Disease: Kufor-rakeb Syndrome

Dos Santos, A.V., et al. Neurosci. Lett. 485(2):121-124(2010)
Reetz, K., et al. Neurobiol. Dis. 39(3):402-408(2010)
Schneider, S.A., et al. Mov. Disord. 25(8):979-984(2010)
Okada, Y., et al. Hum. Mol. Genet. 19(11):2303-2312(2010)
Fei, Q.Z., et al. Neurosci. Lett. 475(2):61-63(2010)

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.