Product Name
ATP13A2, Polyclonal Antibody
Full Product Name
ATP13A2 Antibody
Product Synonym Names
FLJ26510; HSA9947; KRPPD; PARK9
Product Gene Name
anti-ATP13A2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Immunogen
Fusion protein of ATP13A2
Calculated Molecular Weight: 1158aa; 126kd
Buffer
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-ATP13A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ATP13A2 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for ATP13A2. It may not necessarily be applicable to this product.
NCBI Accession #
AAH34575.1
[Other Products]
UniProt Secondary Accession #
O75700; Q5JXY1; Q5JXY2; Q6S9Z9[Other Products]
UniProt Related Accession #
Q9NQ11[Other Products]
Molecular Weight
128,323 Da
NCBI Official Full Name
ATP13A2 protein, partial
NCBI Official Synonym Full Names
ATPase type 13A2
NCBI Official Symbol
ATP13A2??[Similar Products]
NCBI Official Synonym Symbols
CLN12; KRPPD; PARK9; HSA9947
??[Similar Products]
NCBI Protein Information
probable cation-transporting ATPase 13A2
UniProt Protein Name
Probable cation-transporting ATPase 13A2
Protein Family
Probable cation-transporting ATPase
UniProt Gene Name
ATP13A2??[Similar Products]
UniProt Synonym Gene Names
PARK9??[Similar Products]
UniProt Entry Name
AT132_HUMAN
NCBI Summary for ATP13A2
This gene encodes a member of the P5 subfamily of ATPases which transports inorganic cations as well as other substrates. Mutations in this gene are associated with Kufor-Rakeb syndrome (KRS), also referred to as Parkinson disease 9. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2008]
UniProt Comments for ATP13A2
ATP13A2: May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity. Expressed in brain; protein levels are markedly increased in brain from subjects with Parkinson disease and subjects with dementia with Lewy bodies. Detected in pyramidal neurons located throughout the cingulate cortex. In the substantia nigra, it is found in neuromelanin- positive dopaminergic neurons. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.6.3.-; Membrane protein, multi-pass; Transporter; Hydrolase; Transporter, ion channel; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p36
Cellular Component: lysosomal membrane; lysosome; integral to membrane
Molecular Function: protein binding; metal ion binding; ATPase activity; ATP binding
Biological Process: metabolic process; cation transport
Disease: Kufor-rakeb Syndrome
Research Articles on ATP13A2
1. Reduced ATP13A2 expression significantly decreased vesicular zinc levels, indicating ATP13A2 facilitates transport of zinc.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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