Full Product Name
K1C12 Polyclonal Antibody
Product Synonym Names
Keratin, type I cytoskeletal 12; Cytokeratin-12; CK-12; Keratin-12; K12; KRT12
Product Gene Name
anti-K1C12 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q99456
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Immunogen
Synthesized peptide derived from human protein. at AA range: 200-280
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-K1C12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-K1C12 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-K1C12 antibody
WB: 1:500-2000
ELISA: 1:5000-20000
NCBI/Uniprot data below describe general gene information for K1C12. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000214.1
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NCBI GenBank Nucleotide #
NM_000223.3
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UniProt Primary Accession #
Q99456
[Other Products]
UniProt Secondary Accession #
B2R9E0[Other Products]
UniProt Related Accession #
Q99456[Other Products]
NCBI Official Full Name
keratin, type I cytoskeletal 12
NCBI Official Synonym Full Names
keratin 12
NCBI Official Symbol
KRT12??[Similar Products]
NCBI Official Synonym Symbols
K12
??[Similar Products]
NCBI Protein Information
keratin, type I cytoskeletal 12
UniProt Protein Name
Keratin, type I cytoskeletal 12
UniProt Synonym Protein Names
Cytokeratin-12; CK-12; Keratin-12; K12
UniProt Gene Name
KRT12??[Similar Products]
UniProt Synonym Gene Names
CK-12; K12??[Similar Products]
NCBI Summary for K1C12
KRT12 encodes the type I intermediate filament chain keratin 12, expressed in corneal epithelia. Mutations in this gene lead to Meesmann corneal dystrophy. [provided by RefSeq, Jul 2008]
UniProt Comments for K1C12
May play a unique role in maintaining the normal corneal epithelial function. Together with KRT3, essential for the maintenance of corneal epithelium integrity ().
Research Articles on K1C12
1. A) in the TGFBI gene and insert mutation (c.1456-1457ins GAT) in the KRT12 gene were identified in a 23-year-old male patient with concurrent KC and GCD.">KC can co-exist with GCD. The missense mutation (c.370G > A) in the TGFBI gene and insert mutation (c.1456-1457ins GAT) in the KRT12 gene were identified in a 23-year-old male patient with concurrent KC and GCD.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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