Full Product Name
K2C3 Antibody
Product Synonym Names
Keratin; type II cytoskeletal 3
Product Gene Name
anti-K2C3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P12035
Specificity
K2C3 Antibody detects endogenous levels of total K2C3
Form/Format
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0mg/mL (lot specific)
Immunogen
A synthesized peptide derived from human K2C3
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-K2C3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-K2C3 antibody
Total protein Ab
Applications Tested/Suitable for anti-K2C3 antibody
Western Blot (WB)
Application Notes for anti-K2C3 antibody
Western Blot: 1:1000-3000
Western Blot (WB) of anti-K2C3 antibody
Western blot analysis K2C3 using COLO205 whole cell lysates
NCBI/Uniprot data below describe general gene information for K2C3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_476429.2
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NCBI GenBank Nucleotide #
NM_057088.2
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UniProt Primary Accession #
P12035
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UniProt Secondary Accession #
Q701L8; A6NIS2[Other Products]
UniProt Related Accession #
P12035[Other Products]
Molecular Weight
64,417 Da
NCBI Official Full Name
keratin, type II cytoskeletal 3
NCBI Official Synonym Full Names
keratin 3
NCBI Official Symbol
KRT3??[Similar Products]
NCBI Official Synonym Symbols
K3; CK3
??[Similar Products]
NCBI Protein Information
keratin, type II cytoskeletal 3
UniProt Protein Name
Keratin, type II cytoskeletal 3
UniProt Synonym Protein Names
65 kDa cytokeratin; Cytokeratin-3; CK-3; Keratin-3; K3; Type-II keratin Kb3
UniProt Gene Name
KRT3??[Similar Products]
UniProt Synonym Gene Names
CK-3; K3??[Similar Products]
UniProt Entry Name
K2C3_HUMAN
NCBI Summary for K2C3
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the corneal epithelium with family member KRT12 and mutations in these genes have been associated with Meesmann's Corneal Dystrophy. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
UniProt Comments for K2C3
K3: a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K12.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component: keratin filament
Molecular Function: structural molecule activity
Biological Process: epithelial cell differentiation; intermediate filament cytoskeleton organization and biogenesis
Disease: Corneal Dystrophy, Meesmann
Research Articles on K2C3
1. we show that the two PAX6 isoforms differentially and cooperatively regulate the expression of genes specific to the structure and functions of the corneal epithelium, particularly keratin 3 (KRT3) and keratin 12 (KRT12). PAX6 isoform-a induced KRT3 expression by targeting its upstream region. KLF4 enhanced this induction. A combination of PAX6 isoform-b, KLF4, and OCT4 induced KRT12 expression
Precautions
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Disclaimer
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