Product Name
Keratin 12 (KRT12), Polyclonal Antibody
Full Product Name
Cy3-Linked Polyclonal Antibody to Keratin 12 (KRT12)
Product Synonym Names
CK12; K12; Cytokeratin 12; Meesmann Corneal Dystrophy; Keratin, type I cytoskeletal 12
Product Gene Name
anti-KRT12 antibody
[Similar Products]
Matching Pairs
Unconjugated Antibody: Keratin 12 (KRT12) (MBS2005361)
Cy3 Conjugated Antibody: Keratin 12 (KRT12) (MBS2043544)
Matching Pairs
Cy3 Conjugated Antibody: Keratin 12 (KRT12) (MBS2043544)
Immunogen: Keratin 12 (KRT12) (MBS2011435)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Concentration
200ug/ml (lot specific)
Immunogen
KRT12 (Asp398~Met456)
Unconjugated Antibody
The unconjugated antibody version of this item is also available as catalog #MBS2005361
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customera??s specifications, please inquire.
Other Notes
Small volumes of anti-KRT12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-KRT12 antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)
NCBI/Uniprot data below describe general gene information for KRT12. It may not necessarily be applicable to this product.
NCBI Accession #
AAF61432.1
[Other Products]
UniProt Secondary Accession #
B2R9E0[Other Products]
UniProt Related Accession #
Q99456[Other Products]
Molecular Weight
53,511 Da
NCBI Official Full Name
keratin 12
NCBI Official Synonym Full Names
keratin 12
NCBI Official Symbol
KRT12??[Similar Products]
NCBI Official Synonym Symbols
K12
??[Similar Products]
NCBI Protein Information
keratin, type I cytoskeletal 12
UniProt Protein Name
Keratin, type I cytoskeletal 12
UniProt Synonym Protein Names
Cytokeratin-12; CK-12; Keratin-12; K12
UniProt Gene Name
KRT12??[Similar Products]
UniProt Synonym Gene Names
CK-12; K12??[Similar Products]
NCBI Summary for KRT12
KRT12 encodes the type I intermediate filament chain keratin 12, expressed in corneal epithelia. Mutations in this gene lead to Meesmann corneal dystrophy. [provided by RefSeq, Jul 2008]
UniProt Comments for KRT12
K12: May play a unique role in maintaining the normal corneal epithelial function. Together with KRT3, essential for the maintenance of corneal epithelium integrity. Defects in KRT12 are a cause of Meesmann corneal dystrophy (MECD); also abbreviated MCD and known as juvenile epithelial corneal dystrophy of Meesmann. MECD is an autosomal dominant disease that causes fragility of the anterior corneal epithelium. Patients are usually asymptomatic until *****hood when rupture of the corneal microcysts may cause erosions, producing clinical symptoms such as photophobia, contact lens intolerance and intermittent diminution of visual acuity. Rarely, subepithelial scarring causes irregular corneal astigmatism and permanent visual impairment. Histological examination shows a disorganized and thickened epithelium with widespread cytoplasmic vacuolation and numerous small, round, debris-laden intraepithelial cysts. Belongs to the intermediate filament family.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 17q21.2
Biological Process: visual perception
Disease: Corneal Dystrophy, Meesmann
Research Articles on KRT12
1. we show that the two PAX6 isoforms differentially and cooperatively regulate the expression of genes specific to the structure and functions of the corneal epithelium, particularly keratin 3 (KRT3) and keratin 12 (KRT12). PAX6 isoform-a induced KRT3 expression by targeting its upstream region. KLF4 enhanced this induction. A combination of PAX6 isoform-b, KLF4, and OCT4 induced KRT12 expression
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
