For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 17; NC_000017.10 (39017430..39023462, complement). Location: 17q12

Store all reagents at 2-8 degree C

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Small volumes of KRT12 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9311743 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Keratin 12 (KRT12) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing KRT12. The ELISA analytical biochemical technique of the MBS9311743 kit is based on KRT12 antibody-KRT12 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect KRT12 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, KRT12. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

53,511 Da

keratin 12

keratin, type I cytoskeletal 12; CK-12; keratin-12; cytokeratin-12

Keratin, type I cytoskeletal 12

CK-12; K12??[Similar Products]

K1C12_HUMAN

KRT12 encodes the type I intermediate filament chain keratin 12, expressed in corneal epithelia. Mutations in this gene lead to Meesmann corneal dystrophy. [provided by RefSeq, Jul 2008]

K12: May play a unique role in maintaining the normal corneal epithelial function. Together with KRT3, essential for the maintenance of corneal epithelium integrity. Defects in KRT12 are a cause of Meesmann corneal dystrophy (MECD); also abbreviated MCD and known as juvenile epithelial corneal dystrophy of Meesmann. MECD is an autosomal dominant disease that causes fragility of the anterior corneal epithelium. Patients are usually asymptomatic until *****hood when rupture of the corneal microcysts may cause erosions, producing clinical symptoms such as photophobia, contact lens intolerance and intermittent diminution of visual acuity. Rarely, subepithelial scarring causes irregular corneal astigmatism and permanent visual impairment. Histological examination shows a disorganized and thickened epithelium with widespread cytoplasmic vacuolation and numerous small, round, debris-laden intraepithelial cysts. Belongs to the intermediate filament family.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: intermediate filament

Molecular Function: structural molecule activity

Biological Process: visual perception

Disease: Corneal Dystrophy, Meesmann

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