Product Name
SLC30A8, Blocking Peptide
Full Product Name
SLC30A8 Peptide
Product Synonym Names
SLC30A8
Antibody; Solute carrier family 30 member 8; zinc transporter 8; ZNT8; Zn-T8
Product Gene Name
SLC30A8 blocking peptide
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Antibody/Peptide Pairs
SLC30A8 peptide (MBS154491) is used for blocking the activity of SLC30A8 antibody (MBS154449)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
14 amino acid peptide near the amino terminus of human SLC30A8.
Sequence
CHSGSKPTEK GANEY
3D Structure
ModBase 3D Structure for Q8IWU4
Concentration
200 ug/mL (lot specific)
Buffer
PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
Preparation and Storage
Store at -20 degree C, stable for one year.
Other Notes
Small volumes of SLC30A8 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for SLC30A8 blocking peptide
Blocking (BL)
NCBI/Uniprot data below describe general gene information for SLC30A8. It may not necessarily be applicable to this product.
NCBI Accession #
NP_776250
[Other Products]
NCBI GenBank Nucleotide #
NM_173851.2
[Other Products]
UniProt Primary Accession #
Q8IWU4
[Other Products]
UniProt Secondary Accession #
Q8TCL3; A0AVP9; A5YM39; B4DPE0[Other Products]
UniProt Related Accession #
Q8IWU4[Other Products]
Molecular Weight
35,053 Da
NCBI Official Full Name
zinc transporter 8 isoform a
NCBI Official Synonym Full Names
solute carrier family 30 member 8
NCBI Official Symbol
SLC30A8??[Similar Products]
NCBI Official Synonym Symbols
ZNT8; ZnT-8
??[Similar Products]
NCBI Protein Information
zinc transporter 8
UniProt Protein Name
Zinc transporter 8
UniProt Synonym Protein Names
Solute carrier family 30 member 8
Protein Family
Zinc transporter
UniProt Gene Name
SLC30A8??[Similar Products]
UniProt Synonym Gene Names
ZNT8; ZnT-8??[Similar Products]
NCBI Summary for SLC30A8
The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]
UniProt Comments for SLC30A8
SLC30A8: Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta- cells. Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family; Vesicle
Chromosomal Location of Human Ortholog: 8q24.11
Cellular Component: cytoplasmic vesicle; Golgi apparatus; plasma membrane; secretory granule; secretory granule membrane
Molecular Function: protein binding; protein homodimerization activity; zinc ion binding; zinc ion transmembrane transporter activity
Biological Process: cellular zinc ion homeostasis; glucose homeostasis; insulin secretion; positive regulation of insulin secretion; response to glucose stimulus; response to zinc ion; sequestering of zinc ion; zinc ion transport
Disease: Diabetes Mellitus, Noninsulin-dependent
Product References and Citations for SLC30A8 blocking peptide
Chimienti F, Devergnas S, Favier A, et al. Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules. Diabetes 2004; 53:2330-7.
Research Articles on SLC30A8
1. this is the first study to report a significant association between the R325W C-allele of SLC30A8 and increased risk of developing gestational diabetes mellitus. All of the autoantibody positive women with GDM who developed postpartum type 1 diabetes were positive for autoantibodies against glutamic acid decarboxylase. Thus ZnT8A did not have any additional predictive value in postpartum development of type 1 diabetes.
Precautions
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Disclaimer
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