Product Name
ABCC10, Polyclonal Antibody
Full Product Name
Anti-ABCC10 Antibody
Product Gene Name
anti-ABCC10 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human. Not yet tested in other species
Purity/Purification
Affinity purified
Concentration
100ug/100ul (lot specific)
Storage Buffer
PBS, pH 7.4 with 0.02% Sodium Azide
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Other Notes
Small volumes of anti-ABCC10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ABCC10 antibody
This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2010]
Applications Tested/Suitable for anti-ABCC10 antibody
Peptide ELISA (EIA), Western Blot, Immunohistochemistry (IHC)
Application Notes for anti-ABCC10 antibody
Peptide ELISA titer: 1:10,000-1:40,000
Western blot analysis: 1:500-1:1,000
Immunohistochemistry: 1:100-1:500
Optimal dilutions/concentrations should be determined by the end user.
Western Blot (WB) of anti-ABCC10 antibody
NCBI/Uniprot data below describe general gene information for ABCC10. It may not necessarily be applicable to this product.
NCBI Accession #
AAH24103.1
[Other Products]
UniProt Secondary Accession #
Q8NHX7; Q9H7N2; Q9NXY3; Q9UF48[Other Products]
UniProt Related Accession #
Q5T3U5[Other Products]
Molecular Weight
158,781 Da
NCBI Official Full Name
ABCC10 protein
NCBI Official Synonym Full Names
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
NCBI Official Symbol
ABCC10??[Similar Products]
NCBI Official Synonym Symbols
MRP7; SIMRP7; EST182763
??[Similar Products]
NCBI Protein Information
multidrug resistance-associated protein 7; ATP-binding cassette sub-family C member 10
UniProt Protein Name
Multidrug resistance-associated protein 7
UniProt Synonym Protein Names
ATP-binding cassette sub-family C member 10
Protein Family
ABC transporter C family
UniProt Gene Name
ABCC10??[Similar Products]
UniProt Entry Name
MRP7_HUMAN
NCBI Summary for ABCC10
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2010]
UniProt Comments for ABCC10
ABCC10: ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Transporter, ABC family; Membrane protein, integral; Transporter
Chromosomal Location of Human Ortholog: 6p21.1
Cellular Component: lysosomal membrane; plasma membrane; integral to membrane
Molecular Function: ATPase activity, coupled to transmembrane movement of substances; ATP binding
Biological Process: metabolic process; transmembrane transport
Product References and Citations for anti-ABCC10 antibody
(1) Kuang,Y.H., Shen,T., Chen,X., et al. Lapatinib and erlotinib are potent reversal agents for MRP7 (ABCC10)-mediated multidrug resistance. Biochem. Pharmacol. 79 (2), 154-161 (2010)
Research Articles on ABCC10
1. the combination of paclitaxel and masitinib could serve as a novel and useful therapeutic strategy to reverse paclitaxel resistance mediated by ABCC10
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
