Product Name
ABCC10, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human ABCC10
Product Synonym Names
Anti-ABCC10 Antibody (aa816-865) IHC-plus; ABCC10; EST182763; Multidrug resistance protein 7; MRP7; SIMRP7; Human ABCC10
Product Gene Name
anti-ABCC10 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q5T3U5
Specificity
MRP7 Antibodyantibody detects endogenous levels of MRP7.
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Concentration
1 mg/ml (lot specific)
Immunogen Description
Synthetic peptide from human MRP7 (aa816-865).
Immunogen
ABCC10 antibody was raised against synthetic peptide from human MRP7 (aa816-865).
Antigen Modification
aa816-865
Preparation and Storage
Store at -20 degree C.
Other Notes
Small volumes of anti-ABCC10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-ABCC10 antibody
Subfamily:-ATP-binding-cassette---ABCC/MRP">Family: Transporter
Subfamily: ATP-binding cassette - ABCC/MRP
Applications Tested/Suitable for anti-ABCC10 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-ABCC10 antibody
ELISA (1:10000), IHC-P (20 ug/ml), WB (1:500 - 1:1000)
Immunohistochemistry (IHC) of anti-ABCC10 antibody
Anti-ABCC10 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
Western Blot (WB) of anti-ABCC10 antibody
Western blot of the lysates from HepG2 cells using MRP7 antibody.
NCBI/Uniprot data below describe general gene information for ABCC10. It may not necessarily be applicable to this product.
NCBI Accession #
NP_258261.2
[Other Products]
NCBI GenBank Nucleotide #
NM_033450.2
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UniProt Primary Accession #
Q5T3U5
[Other Products]
UniProt Secondary Accession #
Q8NHX7; Q9H7N2; Q9NXY3; Q9UF48[Other Products]
UniProt Related Accession #
Q5T3U5[Other Products]
Molecular Weight
158,781 Da
NCBI Official Full Name
multidrug resistance-associated protein 7 isoform MRP7A
NCBI Official Synonym Full Names
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
NCBI Official Symbol
ABCC10??[Similar Products]
NCBI Official Synonym Symbols
MRP7; SIMRP7; EST182763
??[Similar Products]
NCBI Protein Information
multidrug resistance-associated protein 7; ATP-binding cassette sub-family C member 10
UniProt Protein Name
Multidrug resistance-associated protein 7
UniProt Synonym Protein Names
ATP-binding cassette sub-family C member 10
Protein Family
ABC transporter C family
UniProt Gene Name
ABCC10??[Similar Products]
UniProt Synonym Gene Names
MRP7; SIMRP7??[Similar Products]
UniProt Entry Name
MRP7_HUMAN
NCBI Summary for ABCC10
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2010]
UniProt Comments for ABCC10
ABCC10: ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Transporter, ABC family; Transporter; Membrane protein, integral
Chromosomal Location of Human Ortholog: 6p21.1
Cellular Component: lysosomal membrane; integral to membrane; plasma membrane
Molecular Function: ATPase activity, coupled to transmembrane movement of substances; ATP binding
Biological Process: metabolic process; transmembrane transport
Research Articles on ABCC10
1. the combination of paclitaxel and masitinib could serve as a novel and useful therapeutic strategy to reverse paclitaxel resistance mediated by ABCC10
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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