Ribose-phosphate pyrophosphokinase 1; ARTS; CMTX5; PPRibP; PRSI; DFN2; DFNX1; Ribose-phosphate pyrophosphokinase 1 EC 2.7.6.1; KIAA0967; Phosphoribosyl pyrophosphate synthetase I; PRS I; PRS-I; Ribose phosphate pyrophosphokinase I

For Research Use Only. Not for use in diagnostic procedures.

E Coli

> 90% by SDS-PAGE

Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 1mM DTT, 0.1 M NaCl, and 20% glycerol

0.5 mg/ml (determined by Bradford assay) (lot specific)

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Small volumes of PRPS1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

PRPS1, also known as ribose-phosphate pyrophosphokinase 1, is ubiquitously expressed in human tissues. This enzyme catalyzes the phosphoribosylation of ribose 5-phosphate to 5-phosphoribosyl-1-pyrophosphate, which is necessary for purine metabolism and nucleotide biosynthesis. Recombinant human PRPS1 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.

Enzymes & Proteases

SDS-PAGE

36.9 kDa (338aa), confirmed by MALDI-TOF.

phosphoribosyl pyrophosphate synthetase 1

ribose-phosphate pyrophosphokinase 1

Ribose-phosphate pyrophosphokinase 1

PRS-I??[Similar Products]

This gene encodes an enzyme that catalyzes the phosphoribosylation of ribose 5-phosphate to 5-phosphoribosyl-1-pyrophosphate, which is necessary for purine metabolism and nucleotide biosynthesis. Defects in this gene are a cause of phosphoribosylpyrophosphate synthetase superactivity, Charcot-Marie-Tooth disease X-linked recessive type 5 and Arts Syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.

Liu H., et al. (2009) Biochem Biophys Res Commun. 379 (4):1120-5. ; Li S., et al. (2007) Biochem J. 401 (1):39-47.;

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