Product Name
ABCC11, Polyclonal Antibody
Full Product Name
ABCC11 Antibody
Product Synonym Names
ABCC11; EWWD; Multi-resistance protein 8; MRP8; WW
Product Gene Name
anti-ABCC11 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q96J66
Specificity
ABCC11 Antibody detects endogenous levels of total ABCC11
Form/Format
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0mg/mL (lot specific)
Immunogen
A synthesized peptide derived from human ABCC11
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-ABCC11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-ABCC11 antibody
Total protein Ab
Applications Tested/Suitable for anti-ABCC11 antibody
Western Blot (WB)
Application Notes for anti-ABCC11 antibody
Western Blot: 1:1000-3000
Western Blot (WB) of anti-ABCC11 antibody
Western blot analysis ABCC11 using Jurkat whole cell lysates
NCBI/Uniprot data below describe general gene information for ABCC11. It may not necessarily be applicable to this product.
NCBI Accession #
NP_115972.2
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NCBI GenBank Nucleotide #
NM_032583.3
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UniProt Primary Accession #
Q96J66
[Other Products]
UniProt Secondary Accession #
Q8TDJ0; Q96JA6; Q9BX80[Other Products]
UniProt Related Accession #
Q96J66[Other Products]
Molecular Weight
150,093 Da
NCBI Official Full Name
ATP-binding cassette sub-family C member 11 isoform a
NCBI Official Synonym Full Names
ATP binding cassette subfamily C member 11
NCBI Official Symbol
ABCC11??[Similar Products]
NCBI Official Synonym Symbols
WW; EWWD; MRP8
??[Similar Products]
NCBI Protein Information
ATP-binding cassette sub-family C member 11
UniProt Protein Name
ATP-binding cassette sub-family C member 11
UniProt Synonym Protein Names
Multidrug resistance-associated protein 8
Protein Family
ABC transporter C family
UniProt Gene Name
ABCC11??[Similar Products]
UniProt Synonym Gene Names
MRP8??[Similar Products]
UniProt Entry Name
ABCCB_HUMAN
NCBI Summary for ABCC11
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCC11
ABCC11: Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. Probably functions to secrete earwax. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family
Chromosomal Location of Human Ortholog: 16q12.1
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: anion transmembrane-transporting ATPase activity; organic anion transmembrane transporter activity; purine nucleotide transmembrane transporter activity
Biological Process: organic anion transport; purine nucleotide transport; transmembrane transport
Disease: Apocrine Gland Secretion, Variation In
Research Articles on ABCC11
1. T (T546M), previously associated with 5-FU-related toxicity, as a novel functionally damaging ABCC11 variant exhibiting markedly reduced transport function of 5-FdUMP, the active cytotoxic metabolite of 5-FU. Detailed analysis of 14 subpopulations revealed highest allele frequencies of c.1637C>T in Europeans and Americans (up to 11%) compared with Africans and Asians (up to 3%).">identified c.1637C>T (T546M), previously associated with 5-FU-related toxicity, as a novel functionally damaging ABCC11 variant exhibiting markedly reduced transport function of 5-FdUMP, the active cytotoxic metabolite of 5-FU. Detailed analysis of 14 subpopulations revealed highest allele frequencies of c.1637C>T in Europeans and Americans (up to 11%) compared with Africans and Asians (up to 3%).
Precautions
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