Product Name
Acyloxyacyl hydrolase (Aoah), Recombinant Protein
Full Product Name
Recombinant Mouse Acyloxyacyl hydrolase (Aoah)
Product Gene Name
Aoah recombinant protein
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
34-155aa, Full Length of Mature Protein
Sequence
YSHGQSCLGC VVLVSVIEQL AEVHNSSVQV AMERLCSYLP EKLFLKTACY FLVQTFGSDI IKLLDEAMKA DVVCYALEFC KRGAVQPQCH LYPLPQEAWE SALEKARQVL RRSSTMKYPR SG
3D Structure
ModBase 3D Structure for O35298
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Aoah recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Aoah recombinant protein
Acyloxyacyl hydrolase (AOAH) is a 2-subunit lipase which selectively hydrolyzes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial endotoxins. AOAH may modulate host inflammatory responses to gram-negative bacterial invasion. The 2 subunits are encoded by a single mRNA.
NCBI/Uniprot data below describe general gene information for Aoah. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001268783.1
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NCBI GenBank Nucleotide #
NM_001281854.1
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UniProt Primary Accession #
O35298
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UniProt Related Accession #
O35298[Other Products]
Molecular Weight
65,155 Da
NCBI Official Full Name
acyloxyacyl hydrolase isoform 2 preproprotein
NCBI Official Synonym Full Names
acyloxyacyl hydrolase
NCBI Official Symbol
Aoah??[Similar Products]
NCBI Official Synonym Symbols
4930433E13Rik
??[Similar Products]
NCBI Protein Information
acyloxyacyl hydrolase
UniProt Protein Name
Acyloxyacyl hydrolase
Protein Family
Acyloxyacyl hydrolase
UniProt Gene Name
Aoah??[Similar Products]
NCBI Summary for Aoah
This genes encodes an enzyme that catalyzes the hydrolysis of acyloxylacyl-linked fatty acyl chains from bacterial lipopolysaccharides. The encoded protein modulates host inflammatory response to gram-negative bacteria. The proprotein is further cleaved into a large and small chain that interact in a heterodimer. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Aug 2013]
UniProt Comments for Aoah
Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides (LPS) (PubMed:12810692, PubMed:15155618, PubMed:17322564, PubMed:19860560). By breaking down LPS, terminates the host response to bacterial infection and prevents prolonged and damaging inflammatory responses (PubMed:17322564, PubMed:19860560, PubMed:28622363). In peritoneal macrophages, seems to be important for recovery from a state of immune tolerance following infection by Gram-negative bacteria (PubMed:18779055).
Research Articles on Aoah
1. Alveolar macrophages increase AOAH expression upon exposure to lipopolysaccharide and that Aoah+/+ mice recover more rapidly than do Aoah-/- mice from acute lung injury induced by nasally instilled lipopolysaccharide or Klebsiella pneumonia.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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