Product Name
Keratin 3 (KRT3), Polyclonal Antibody
Full Product Name
APC-Linked Polyclonal Antibody to Keratin 3 (KRT3)
Product Synonym Names
CK3; K3; Cytokeratin 3; Keratin, type II cytoskeletal 3; 65 kDa cytokeratin; Type-II keratin Kb3
Product Gene Name
anti-KRT3 antibody
[Similar Products]
Matching Pairs
Unconjugated Antibody: Keratin 3 (MBS2028366)
APC Conjugated Antibody: Keratin 3 (KRT3) (MBS2043033)
Matching Pairs
APC Conjugated Antibody: Keratin 3 (KRT3) (MBS2043033)
Immunogen: Keratin 3 (MBS2031496)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Concentration
200ug/ml (lot specific)
Immunogen
KRT3 (Glu198~Ser514)
Unconjugated Antibody
The unconjugated antibody version of this item is also available as catalog #MBS2028366
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customera??s specifications, please inquire.
Other Notes
Small volumes of anti-KRT3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-KRT3 antibody
Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA)
NCBI/Uniprot data below describe general gene information for KRT3. It may not necessarily be applicable to this product.
NCBI Accession #
CAF31522.1
[Other Products]
UniProt Secondary Accession #
Q701L8; A6NIS2[Other Products]
UniProt Related Accession #
P12035[Other Products]
Molecular Weight
64,417 Da
NCBI Official Full Name
keratin 3
NCBI Official Synonym Full Names
keratin 3
NCBI Official Symbol
KRT3??[Similar Products]
NCBI Official Synonym Symbols
K3; CK3
??[Similar Products]
NCBI Protein Information
keratin, type II cytoskeletal 3
UniProt Protein Name
Keratin, type II cytoskeletal 3
UniProt Synonym Protein Names
65 kDa cytokeratin; Cytokeratin-3; CK-3; Keratin-3; K3; Type-II keratin Kb3
UniProt Gene Name
KRT3??[Similar Products]
UniProt Synonym Gene Names
CK-3; K3??[Similar Products]
NCBI Summary for KRT3
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the corneal epithelium with family member KRT12 and mutations in these genes have been associated with Meesmann's Corneal Dystrophy. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
UniProt Comments for KRT3
K3: a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K12.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component: keratin filament
Molecular Function: structural molecule activity
Biological Process: epithelial cell differentiation; intermediate filament cytoskeleton organization and biogenesis
Disease: Corneal Dystrophy, Meesmann
Research Articles on KRT3
1. we show that the two PAX6 isoforms differentially and cooperatively regulate the expression of genes specific to the structure and functions of the corneal epithelium, particularly keratin 3 (KRT3) and keratin 12 (KRT12). PAX6 isoform-a induced KRT3 expression by targeting its upstream region. KLF4 enhanced this induction. A combination of PAX6 isoform-b, KLF4, and OCT4 induced KRT12 expression
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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