Mouse Homeobox protein MSX-2 (MSX2) ELISA kit; CRS2; FPP; HOX8; MSH; PFM; PFM1; msh homeo box 2; msh homeobox homolog 2; msh homeobox 2

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.

Small volumes of MSX2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9333244 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the msh homeobox 2 (MSX2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing MSX2. The ELISA analytical biochemical technique of the MBS9333244 kit is based on MSX2 antibody-MSX2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect MSX2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, MSX2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

28,915 Da

msh homeobox 2

homeobox protein MSX-2; homeobox, msh-like 2; homeo box, msh-like 2; homeobox protein Hox-8-1

Homeobox protein MSX-2

Hox-8.1; Msx-2??[Similar Products]

MSX2_MOUSE

MSX2: Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter. Defects in MSX2 are the cause of parietal foramina 1 (PFM1); also known as foramina parietalia permagna (FPP). PFM1 is an autosomal dominant disease characterized by oval defects of the parietal bones caused by deficient ossification around the parietal notch, which is normally obliterated during the fifth fetal month. Defects in MSX2 are the cause of parietal foramina with cleidocranial dysplasia (PFMCCD); also known as cleidocranial dysplasia with parietal foramina. PFMCCD combines skull defects in the form of enlarged parietal foramina and deficient ossification of the clavicles. Defects in MSX2 are the cause of craniosynostosis type 2 (CRS2); also known as craniosynostosis Boston-type (CSB). CRS2 is an autosomal dominant disorder characterized by the premature fusion of calvarial sutures. The craniosynostosis phenotype is either fronto-orbital recession, or frontal bossing, or turribrachycephaly, or cloverleaf skull. Associated features include severe headache, high incidence of visual problems (myopia or hyperopia), and short first metatarsals. Intelligence is normal. Belongs to the Msh homeobox family.

Protein type: Transcription, coactivator/corepressor; DNA-binding

Cellular Component: transcription factor complex; nucleus

Molecular Function: protein binding; DNA binding; sequence-specific DNA binding; transcription cofactor activity; transcription factor binding

Biological Process: embryonic forelimb morphogenesis; transcription from RNA polymerase II promoter; wound healing; positive regulation of apoptosis; multicellular organismal development; negative regulation of transcription from RNA polymerase II promoter; embryonic hindlimb morphogenesis; regulation of apoptosis; anterior/posterior pattern formation; BMP signaling pathway; odontogenesis; negative regulation of cell proliferation; regulation of transcription, DNA-dependent; positive regulation of BMP signaling pathway; embryonic limb morphogenesis; ossification; transcription, DNA-dependent; negative regulation of keratinocyte differentiation; chondrocyte development; stem cell differentiation; negative regulation of fat cell differentiation; positive regulation of catagen; osteoblast development; osteoblast differentiation; regulation of transcription from RNA polymerase II promoter; positive regulation of osteoblast differentiation; cartilage development; embryonic digit morphogenesis; anagen; inhibition of CREB transcription factor; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis; wound healing, spreading of epidermal cells

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.