Product Name
MSX2, cDNA Clone
Full Product Name
MSX2 cDNA Clone
Product Gene Name
MSX2 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggcttctc cgtccaaagg caatgacttg ttttcgcccg acgaggaggg cccagcagtg gtggccggac caggcccggg gcctgggggc gccgaggggg ccgcggagga gcgccgcgtc aaggtctcca gcctgccctt cagcgtggag gcgctcatgt ccgacaagaa gccgcccaag gaggcgtccc cgctgccggc cgaaagcgcc tcggccgggg ccaccctgcg gccactgctg ctgtcggggc acggcgctcg ggaagcgcac agccccgggc cgctggtgaa gcccttcgag accgcctcgg tcaagtcgga aaattcagaa gatggagcgg cgtggatgca ggaacccggc cgatattcgc cgccgccaag acatacgagc cctaccacct gcaccctgag gaaacacaag accaatcgga agccgcgcac gccctttacc acatcccagc tcctcgccct ggagcgcaag ttccgtcaga aacagtacct ctccattgca gagcgtgcag agttctccag ctctctgaac ctcacagaga cccaggtcaa aatctggttc cagaaccgaa gggccaaggc gaaaagactg caggaggcag aactggaaaa gctgaaaatg gctgcaaaac ctatgctgcc ctccagcttc agtctccctt tccccatcag ctcgcccctg caggcagcgt ccatatatgg agcatcctac ccgttccata gacctgtgct tcccatcccg cctgtgggac tctatgccac gccagtggga tatggcatgt accacctgtc ctaa
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of MSX2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for MSX2. It may not necessarily be applicable to this product.
NCBI Accession #
BC015509
[Other Products]
UniProt Secondary Accession #
Q53XM4; Q9UD60; D3DQN1[Other Products]
UniProt Related Accession #
P35548[Other Products]
Molecular Weight
28,897 Da
NCBI Official Full Name
Homo sapiens msh homeobox 2, mRNA
NCBI Official Synonym Full Names
msh homeobox 2
NCBI Official Symbol
MSX2??[Similar Products]
NCBI Official Synonym Symbols
FPP; MSH; PFM; CRS2; HOX8; PFM1
??[Similar Products]
NCBI Protein Information
homeobox protein MSX-2
UniProt Protein Name
Homeobox protein MSX-2
UniProt Synonym Protein Names
Homeobox protein Hox-8
Protein Family
Msx2-interacting protein
UniProt Gene Name
MSX2??[Similar Products]
UniProt Synonym Gene Names
HOX8??[Similar Products]
UniProt Entry Name
MSX2_HUMAN
NCBI Summary for MSX2
This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2. [provided by RefSeq, Jul 2008]
UniProt Comments for MSX2
MSX2: Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter. Defects in MSX2 are the cause of parietal foramina 1 (PFM1); also known as foramina parietalia permagna (FPP). PFM1 is an autosomal dominant disease characterized by oval defects of the parietal bones caused by deficient ossification around the parietal notch, which is normally obliterated during the fifth fetal month. Defects in MSX2 are the cause of parietal foramina with cleidocranial dysplasia (PFMCCD); also known as cleidocranial dysplasia with parietal foramina. PFMCCD combines skull defects in the form of enlarged parietal foramina and deficient ossification of the clavicles. Defects in MSX2 are the cause of craniosynostosis type 2 (CRS2); also known as craniosynostosis Boston-type (CSB). CRS2 is an autosomal dominant disorder characterized by the premature fusion of calvarial sutures. The craniosynostosis phenotype is either fronto-orbital recession, or frontal bossing, or turribrachycephaly, or cloverleaf skull. Associated features include severe headache, high incidence of visual problems (myopia or hyperopia), and short first metatarsals. Intelligence is normal. Belongs to the Msh homeobox family.
Protein type: DNA-binding; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 5q35.2
Molecular Function: protein binding; sequence-specific DNA binding; transcription cofactor activity
Biological Process: negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; osteoblast differentiation
Disease: Craniosynostosis 2; Parietal Foramina; Parietal Foramina With Cleidocranial Dysplasia
Research Articles on MSX2
1. The MSX2 destabilizes the pluripotency circuitry through direct binding to the SOX2 promoter, while MSX2 controls mesendoderm lineage commitment by simultaneous suppression of SOX2 and induction of NODAL expression.
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Disclaimer
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