Product Name
Keratin K12 (KRT12), Polyclonal Antibody
Full Product Name
Keratin K12 antibody
Product Synonym Names
Polyclonal Keratin K12; Anti Keratin K12; CK-12; K12; Keratin K-12; Cytokeratin 12; Keratin K 12; Keratin 12; Keratin K12
Product Gene Name
anti-KRT12 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q99456
Species Reactivity
Pig, Mouse
Specificity
Human Keratin K12
Form/Format
Supplied in liquid form. Contains 0.09% sodium azide
Biological Significance
Keratin 12 is a protein that in humans is encoded by the KRT12 gene. Keratin 12 is keratin found expressed in corneal epithelia. Mutations in the gene encoding this protein lead to Meesmann corneal dystrophy.
Immunogen
Keratin K12 antibody was raised in Guinea Pig using synthetic peptide of human keratin K12 coupled to KLH as the immunogen.
Preparation and Storage
Store at 2-8 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-KRT12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-KRT12 antibody
Guinea Pig polyclonal Keratin K12 antibody
Product Categories/Family for anti-KRT12 antibody
Cell Biology
Applications Tested/Suitable for anti-KRT12 antibody
Immunofluorescence (IF), Immunohistochemistry (IHC)
Application Notes for anti-KRT12 antibody
IHC: 1:100-200
NCBI/Uniprot data below describe general gene information for KRT12. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000214.1
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NCBI GenBank Nucleotide #
NM_000223.3
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UniProt Primary Accession #
Q99456
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UniProt Secondary Accession #
B2R9E0[Other Products]
UniProt Related Accession #
Q99456[Other Products]
Molecular Weight
53,511 Da[Similar Products]
NCBI Official Full Name
keratin, type I cytoskeletal 12
NCBI Official Synonym Full Names
keratin 12, type I
NCBI Official Symbol
KRT12??[Similar Products]
NCBI Official Synonym Symbols
K12
??[Similar Products]
NCBI Protein Information
keratin, type I cytoskeletal 12
UniProt Protein Name
Keratin, type I cytoskeletal 12
UniProt Synonym Protein Names
Cytokeratin-12; CK-12; Keratin-12; K12
UniProt Gene Name
KRT12??[Similar Products]
UniProt Synonym Gene Names
CK-12; K12??[Similar Products]
UniProt Entry Name
K1C12_HUMAN
NCBI Summary for KRT12
KRT12 encodes the type I intermediate filament chain keratin 12, expressed in corneal epithelia. Mutations in this gene lead to Meesmann corneal dystrophy. [provided by RefSeq, Jul 2008]
UniProt Comments for KRT12
K12: May play a unique role in maintaining the normal corneal epithelial function. Together with KRT3, essential for the maintenance of corneal epithelium integrity. Defects in KRT12 are a cause of Meesmann corneal dystrophy (MECD); also abbreviated MCD and known as juvenile epithelial corneal dystrophy of Meesmann. MECD is an autosomal dominant disease that causes fragility of the anterior corneal epithelium. Patients are usually asymptomatic until *****hood when rupture of the corneal microcysts may cause erosions, producing clinical symptoms such as photophobia, contact lens intolerance and intermittent diminution of visual acuity. Rarely, subepithelial scarring causes irregular corneal astigmatism and permanent visual impairment. Histological examination shows a disorganized and thickened epithelium with widespread cytoplasmic vacuolation and numerous small, round, debris-laden intraepithelial cysts. Belongs to the intermediate filament family.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 17q12
Cellular Component: intermediate filament
Molecular Function: structural molecule activity
Biological Process: visual perception
Disease: Corneal Dystrophy, Meesmann
Research Articles on KRT12
1. Combined with an effective delivery vehicle this siRNA approach represents a viable treatment option for prevention of the MECD pathology observed in K12-Leu132Pro heterozygous individuals.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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