Product Name
COL11A1, Polyclonal Antibody
Full Product Name
COL11A1 Antibody
Product Synonym Names
STL2; COLL6; CO11A1
Product Gene Name
anti-COL11A1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P12107
Specificity
The antibody detects endogenous levels of total COL11A1 protein.
Purity/Purification
Antigen affinity purification
Form/Format
In pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Concentration
0.8mg/ml (lot specific)
Immunogen
Synthetic protein corresponding to internal residues of human COL11A1
Preparation and Storage
Store at -20 degree C.
Other Notes
Small volumes of anti-COL11A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-COL11A1 antibody
This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Mutations in this gene are associated with type II Stickler syndrome and with Marshall syndrome. A single-nucleotide polymorphism in this gene is also associated with susceptibility to lumbar disc herniation. Multiple transcript variants have been identified for this gene.
Product Categories/Family for anti-COL11A1 antibody
Total protein Ab
Applications Tested/Suitable for anti-COL11A1 antibody
Immunohistochemistry (IHC)
Application Notes for anti-COL11A1 antibody
IHC: 1: 25-100
Immunohistochemistry (IHC) of anti-COL11A1 antibody
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using 46531(COL11A1 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200)
Immunohistochemistry (IHC) of anti-COL11A1 antibody
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using 46531(COL11A1 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200)
NCBI/Uniprot data below describe general gene information for COL11A1. It may not necessarily be applicable to this product.
NCBI Accession #
BC117697
[Other Products]
UniProt Primary Accession #
P12107
[Other Products]
UniProt Secondary Accession #
Q14034; Q149N0; Q9UIT4; Q9UIT5; Q9UIT6; B1ASK7; D3DT73; E9PCU0[Other Products]
UniProt Related Accession #
P12107[Other Products]
Molecular Weight
167,752 Da
NCBI Official Full Name
Homo sapiens collagen, type XI, alpha 1, mRNA
NCBI Official Synonym Full Names
collagen type XI alpha 1 chain
NCBI Official Symbol
COL11A1??[Similar Products]
NCBI Official Synonym Symbols
STL2; COLL6; CO11A1
??[Similar Products]
NCBI Protein Information
collagen alpha-1(XI) chain
UniProt Protein Name
Collagen alpha-1(XI) chain
UniProt Gene Name
COL11A1??[Similar Products]
UniProt Synonym Gene Names
COLL6??[Similar Products]
NCBI Summary for COL11A1
This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Mutations in this gene are associated with type II Stickler syndrome and with Marshall syndrome. A single-nucleotide polymorphism in this gene is also associated with susceptibility to lumbar disc herniation. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009]
UniProt Comments for COL11A1
May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils.
Research Articles on COL11A1
1. In this study, three novel and two known mutations in the COL2A1 gene were identified in six of 16 Chinese patients with Stickler syndrome. This is the first study in a cohort of Chinese patients with Stickler syndrome, and the results expand the mutation spectrum of the COL2A1 gene.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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