Product Name
Aldehyde oxidase (AOXA), Recombinant Protein
Full Product Name
Recombinant Human Aldehyde oxidase
Product Synonym Names
Aldehyde oxidase 1; Azaheterocycle hydroxylase (EC:1.17.3.-)
Product Gene Name
AOXA recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
FAD-binding PCMH-type domain, 236-421aa
3D Structure
ModBase 3D Structure for Q06278
Purity/Purification
Greater than 90% as determined by SDS-PAGE.
Form/Format
20mM Tris-HCl based buffer, pH8.0
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
Other Notes
Small volumes of AOXA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for AOXA. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001150.3
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NCBI GenBank Nucleotide #
NM_001159.3
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UniProt Primary Accession #
Q06278
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UniProt Secondary Accession #
O14765; Q53RR8; Q53TV3; Q9BYF0; Q9UPG6[Other Products]
UniProt Related Accession #
Q06278[Other Products]
NCBI Official Full Name
aldehyde oxidase
NCBI Official Synonym Full Names
aldehyde oxidase 1
NCBI Official Symbol
AOX1??[Similar Products]
NCBI Official Synonym Symbols
AO; AOH1
??[Similar Products]
NCBI Protein Information
aldehyde oxidase
UniProt Protein Name
Aldehyde oxidase
UniProt Synonym Protein Names
Aldehyde oxidase 1; Azaheterocycle hydroxylase (EC:1.17.3.-)
Protein Family
Aldehyde oxidase
UniProt Gene Name
AOX1??[Similar Products]
UniProt Synonym Gene Names
AO??[Similar Products]
NCBI Summary for AOXA
Aldehyde oxidase produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide. Aldehyde oxidase is a candidate gene for amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2008]
UniProt Comments for AOXA
AOX1: Aldehyde oxidase produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide. Aldehyde oxidase is a candidate gene for amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2008]
Protein type: Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Cofactor and Vitamin Metabolism - vitamin B6; EC 1.2.3.1; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450
Chromosomal Location of Human Ortholog: 2q33.1
Cellular Component: cytosol; nuclear body
Molecular Function: aldehyde oxidase activity; FAD binding; oxidoreductase activity, acting on the aldehyde or oxo group of donors; xanthine dehydrogenase activity
Biological Process: inflammatory response; vitamin B6 metabolic process; xanthine catabolic process
Research Articles on AOXA
1. Data suggest that substrate specificity of AOX1 includes GDC-0834, an inhibitor of Bruton's tyrosine kinase with potential non-steroidal anti-inflammatory agent activity; in liver cytosol, hydrolysis of GDC-0834 is primarily due to AOX1.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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