Product Name
ALG8, cDNA Clone
Full Product Name
ALG8 cDNA Clone
Product Gene Name
ALG8 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggcggcgc tcacaattgc cacgggtact ggcaattggt tttcggcttt ggcgctcggg gtgactcttc tcaaatgcct tctcatcccc acataccatt ccacagattt tgaagtacac cgaaactggc ttgctatcac tcacagtttg ccaatatcac agtggtatta tgaggcaact tcagagtgga cgttggatta cccccctttc tttgcatggt ttgagtatat cctgtcacat gttgccaaat attttgatca agaaatgctg aatgtccata atttgaatta ctccagctca aggaccttac ttttccagag attttccgtc atctttatgg atgtactctt tgtgtatgct gtccgtgagt gctgtaaatg cattgatgga aaaaaagtgg gtaaagaact tacagaaaag ccaaaattta ttctgtcggt attacttctg tggaacttcg ggttattaat tgtggaccat attcattttc agtacaatgg ctttttattt ggattaatgc tactctccat tgcacgatta tttcagaaaa ggcatatgga aggagcattt ctctttgctg ttctcctaca tttcaagcat atctacctct atgtagcacc agcttatggt gtatatctgc tgcgatccta ctgtttcact gcaaataaac cagatgggtc tattcgatgg aagagtttca gctttgttcg tgttatttcc ctgggactgg ttgttttctt agtttctgct ctttcattgg gtcctttcct ggccttgaat cagctgcctc aagtcttttc ccgactcttt cctttcaaga ggggcctctg tcatgcatat tgggctccaa acttctgggc tttgtacaat gctttggaca aagtgctgtc tgtcatcggt ttgaaattga aatttcttga tcccaacaat attcccaagg cctcaatgac aagtggtttg gttcagcagt tccaacacac agtccttccc tcagtgactc ccttggcaac cctcatctgc acactgattg ccatattgcc ctctattttc tgtctttggt ttaaacccca agggcccaga ggctttctcc gatgtctaac tctttgtgcc ttgagctcct ttatgtttgg gtggcatgtt catgaaaaag ccatacttct agcaattctc ccaatgagcc ttttgtctgt gggaaaagca ggagacgctt cgatttttct gattctgacc acaacaggac attattccct ctttcctctg ctcttcactg caccagaact tcccattaaa atcttactca tgttactatt caccatatat agtatttcgt cactgaagac tttattcaga aaagaaaaac ctctttttaa ttggatggaa actttctacc tgcttggcct ggggcctctg gaagtctgct gtgaatttgt attccctttc acctcctgga aggtgaagta ccccttcatc cctttgttac taacctcagt gtattgtgca gtaggcgtca catatgcttg gttcaaactg tatgtttcag tattgattga ctctgctatt ggcaagacaa agaaacaatg a
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of ALG8 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ALG8. It may not necessarily be applicable to this product.
NCBI Accession #
BC001133
[Other Products]
UniProt Secondary Accession #
O60860; A6NDW6[Other Products]
UniProt Related Accession #
Q9BVK2[Other Products]
Molecular Weight
53,181 Da
NCBI Official Full Name
Homo sapiens asparagine-linked glycosylation 8, alpha-1,3-glucosyltransferase homolog (S. cerevisiae), mRNA
NCBI Official Synonym Full Names
ALG8, alpha-1,3-glucosyltransferase
NCBI Official Symbol
ALG8??[Similar Products]
NCBI Official Synonym Symbols
CDG1H
??[Similar Products]
NCBI Protein Information
probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase
UniProt Protein Name
Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase
UniProt Synonym Protein Names
Asparagine-linked glycosylation protein 8 homolog; Dol-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichyl alpha-1,3-glucosyltransferase; Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase
Protein Family
Glycosyltransferase
UniProt Gene Name
ALG8??[Similar Products]
UniProt Entry Name
ALG8_HUMAN
NCBI Summary for ALG8
This gene encodes a member of the ALG6/ALG8 glucosyltransferase family. The encoded protein catalyzes the addition of the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation of proteins. Mutations in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ih). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for ALG8
ALG8: Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol. Defects in ALG8 are the cause of congenital disorder of glycosylation type 1H (CDG1H). CDGs are a family of severe inherited diseases caused by a defect in protein N- glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Belongs to the ALG6/ALG8 glucosyltransferase family.
Protein type: Membrane protein, multi-pass; EC 2.4.1.265; Membrane protein, integral; Glycan Metabolism - N-glycan biosynthesis; Transferase
Chromosomal Location of Human Ortholog: 11q14.1
Cellular Component: endoplasmic reticulum membrane
Molecular Function: alpha-1,3-mannosyltransferase activity; dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity; dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity
Biological Process: dolichol-linked oligosaccharide biosynthetic process; oligosaccharide-lipid intermediate assembly; protein amino acid N-linked glycosylation
Disease: Congenital Disorder Of Glycosylation, Type Ih
Research Articles on ALG8
1. In ALG8-CDG, isoelectric focusing of transferrin in serum or plasma shows an abnormal sialotransferrin pattern. The diagnosis is confirmed by mutation analysis in ALG8; all patients reported so far had point mutations or small deletions
Precautions
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Disclaimer
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