Recombinant Dynamin-like 120 kDa protein, mitochondrial (Opa1); Dynamin-like 120 kDa protein, mitochondrial; Large GTP-binding protein; LargeG Optic atrophy protein 1 homolog Cleaved into the following chain: 1. Dynamin-like 120 kDa protein, form S1

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 16; NC_000082.6 (29579334..29654602). Location: 16 B2; 16 20.65 cM

E Coli or Yeast or Baculovirus or Mammalian Cell

>=90% (lot specific)

Liquid containing glycerol

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterile filter available upon request.

Low endotoxin available upon request.

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of Opa1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

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optic atrophy 1

dynamin-like 120 kDa protein, mitochondrial; largeG; optic atrophy 1 homolog; large GTP-binding protein; optic atrophy protein 1 homolog

Dynamin-like 120 kDa protein, mitochondrial

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OPA1_MOUSE

OPA1: a dynamin-related GTPase required for mitochondrial fusion and regulation of apoptosis. May form a diffusion barrier for proteins stored in mitochondrial cristae. Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space. Defects in OPA1 are the cause of optic atrophy 1 and deafness. Eight splice-variant isoforms have been described.

Protein type: Membrane protein, integral; Mitochondrial; Apoptosis; Hydrolase; EC 3.6.5.5

Cellular Component: nucleoplasm; mitochondrial crista; mitochondrial outer membrane; membrane; mitochondrion; cytoplasm; dendrite; mitochondrial inner membrane; integral to membrane; mitochondrial intermembrane space

Molecular Function: GTPase activity; protein binding; GTP binding; hydrolase activity; nucleotide binding

Biological Process: inner mitochondrial membrane organization and biogenesis; positive regulation of neuron maturation; mitochondrion organization and biogenesis; mitochondrial genome maintenance; visual perception; mitochondrial fusion; apoptosis; neural tube closure; response to stimulus

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