For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

This item is specific for mouse TIRAP (toll-interleukin 1 receptor domain containing adaptor protein), also known as Mal.

TIRAP is one of a family of TIR domain-containing proteins which serve as adaptor proteins for the Toll-like receptors during the innate immune response. TIRAP is reported to participate in the MyD88-dependent signaling pathways shared by TLR2 and TLR4.

Purified
Purified IgG - liquid

IgG concentration 1.0 mg/ml (lot specific)

Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.

Small volumes of anti-TIRAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS221757 is specific for mouse TIRAP (toll-interleukin 1 receptor domain containing adaptor protein), also known as Mal. TIRAP is one of a family of TIR domain-containing proteins which serve as adaptor proteins for the Toll-like receptors during the innate immune response. TIRAP is reported to participate in the MyD88-dependent signaling pathways shared by TLR2 and TLR4.

Immunohistology Paraffin*, Western Blot (WB)

Immunohistology - Paraffin: Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections.
Western Blotting: Minimum Dilution: 0.5ug/ml; Maximum Dilution: 2.0ug/ml

Western blot analysis of human heart lysate probed with Rabbit anti Mouse TIRAP (MBS221757) at 0.5(A), 1(B) and 2(C) ug/ml

Immunohistochemical staining of human heart with Rabbit anti Mouse TIRAP (MBS221757)

26,035 Da

toll-interleukin 1 receptor (TIR) domain-containing adaptor protein

toll/interleukin-1 receptor domain-containing adapter protein; TIR domain-containing adapter protein; Toll-like receptor 4 adaptor protein; adaptor protein Wyatt; myD88 adapter-like protein

Toll/interleukin-1 receptor domain-containing adapter protein

Mal; TIR domain-containing adapter protein??[Similar Products]

TIRAP_MOUSE

TIRAP: an adapter protein involved in the TLR4 signaling pathway in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, ERK1, ERK2 and JNK, resulting in cytokine secretion and the inflammatory response. Homodimerizes. Also forms heterodimers with MyD88. Binds to TLR4 and IRAK2 via their respective TIR domains. Binds to PKR and TBK1. Does not interact with IRAK1, nor TLR9. Genetic variations in TIRAP can influence susceptibility or resistance to infectious diseases, including invasive pneumococcal disease, malaria and tuberculosis. Three isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Cellular Component: nucleoplasm; intercellular bridge; membrane; endocytic vesicle; cytoplasm; plasma membrane; peroxisome; intracellular

Molecular Function: protein binding; phosphatidylinositol-4,5-bisphosphate binding; protein homodimerization activity; protein kinase C binding; protein heterodimerization activity

Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-12 production; positive regulation of interleukin-6 biosynthetic process; positive regulation of JNK cascade; response to lipopolysaccharide; signal transduction; activation of JNK activity; activation of NF-kappaB transcription factor; positive regulation of interleukin-8 production; toll-like receptor 5 signaling pathway; cell surface receptor linked signal transduction; positive regulation of interleukin-15 production; positive regulation of innate immune response; positive regulation of B cell proliferation; inflammatory response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of toll-like receptor 3 signaling pathway; immune system process; positive regulation of toll-like receptor 4 signaling pathway; positive regulation of tumor necrosis factor production; regulation of interleukin-15 production; positive regulation of toll-like receptor 2 signaling pathway; regulation of innate immune response; defense response to Gram-positive bacterium; response to bacterium; innate immune response; myeloid cell differentiation; regulation of interferon-beta production

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