Product Name
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2), Recombinant Protein
Full Product Name
Recombinant Bovine Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) , partial
Product Gene Name
NOD2 recombinant protein
[Similar Products]
Product Synonym Gene Name
NOD2[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-191; Fragment at the N-terminal, include the CARD 1 and CARD 2 domains
Sequence
MCAQDAFQTQ RSQLVELLVS GSLEGFESIL DRLLSREVLS WEDYEGLSLV GQPISHLARR LLDTIWNKGT WGCEQLTAAV REAQADSQPP ELPSSWDPHS PHPARDLQSH RPAIVRRLYG HVEGVLDLTQ QRGFISQYET DEIRRPIFTS SQRARRLLDL ATVKANGLAA FLLQCIQELP VPLALPFEDA A
3D Structure
ModBase 3D Structure for Q6E804
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of NOD2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
NOD2 recombinant protein
This gene is a member of the Nod1
Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome.
NCBI/Uniprot data below describe general gene information for NOD2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001002889.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001002889.1
[Other Products]
UniProt Primary Accession #
Q6E804
[Other Products]
UniProt Related Accession #
Q6E804[Other Products]
Molecular Weight
112,800 Da
NCBI Official Full Name
nucleotide-binding oligomerization domain-containing protein 2
NCBI Official Synonym Full Names
nucleotide binding oligomerization domain containing 2
NCBI Official Symbol
NOD2??[Similar Products]
NCBI Official Synonym Symbols
CARD15
??[Similar Products]
NCBI Protein Information
nucleotide-binding oligomerization domain-containing protein 2
UniProt Protein Name
Nucleotide-binding oligomerization domain-containing protein 2
UniProt Synonym Protein Names
Caspase recruitment domain-containing protein 15
Protein Family
Nucleotide-binding oligomerization domain-containing protein
UniProt Gene Name
NOD2??[Similar Products]
UniProt Synonym Gene Names
CARD15??[Similar Products]
UniProt Comments for NOD2
Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages. Component of an autophagy-mediated antibacterial pathway together with ATG16L1. Plays also a role in sensing single-stranded RNA (ssRNA) from viruses. Interacts with mitochondrial antiviral signaling/MAVS, leading to activation of interferon regulatory factor-3/IRF3 and expression of type I interferon.
Research Articles on NOD2
1. These results revealed that thermal stress increased the expression levels of NOD1/2 genes and acute inflammatory cytokines which sheds some light on their role on immune response of the host cells during thermal stress.These preliminary studies indicated that the immune-related genes differentially expressed during thermal stress among native and crossbred cattle.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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