5-hydroxytryptamine receptor 1B; 5-HT-1B; Serotonin receptor 1B; 5-HT1B; 5-HT-1D-beta; Serotonin 1D beta receptor; S12; HTR1B; HTR1DB

For Research Use Only. Not for use in diagnostic procedures.

5-HT-1B antibody detects endogenous levels of total 5-HT-1B protein.

Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Store at-20 degree C for 1 year.

Small volumes of anti-5-HT-1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

IHC: 1:50-1:100
IF: 1:100-1:500
ELISA: 1:5000

Peptide-+

Peptide-+ Immunohistochemistry analysis of paraffin-embedded human brain tissue, using 5-HT-1B antibody. Immunofluorescence analysis of HeLa cells, using 5-HT-1B antibody.

43,568 Da

5-hydroxytryptamine receptor 1B

5-hydroxytryptamine receptor 1B

5-hydroxytryptamine receptor 1B

HTR1DB; 5-HT-1B; 5-HT1B; 5-HT-1D-beta??[Similar Products]

The protein encoded by this intronless gene is a G-protein coupled receptor for serotonin (5-hydroxytryptamine). Ligand binding activates second messengers that inhibit the activity of adenylate cyclase and manage the release of serotonin, dopamine, and acetylcholine in the brain. The encoded protein may be involved in several neuropsychiatric disorders and therefore is often a target of antidepressant and other psychotherapeutic drugs. [provided by RefSeq, Nov 2015]

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.

Weinshank R.L., Proc. Natl. Acad. Sci. U.S.A. 89:3630-3634(1992). Demchyshyn L., Proc. Natl. Acad. Sci. U.S.A. 89:5522-5526(1992). Mochizuki D., Biochem. Biophys. Res. Commun. 185:517-523(1992).

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