For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 6; NC_000006.11 (78171948..78173120, complement). Location: 6q13

Rabbit

Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

1 mg/ml (lot specific)

Small volumes of anti-5-HT-1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

ELISA (EIA), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)

43,568 Da

5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled

5-hydroxytryptamine receptor 1B; 5-HT-1B; 5-HT-1D-beta; serotonin receptor 1B; serotonin 1D beta receptor

5-hydroxytryptamine receptor 1B

HTR1DB; 5-HT-1B; 5-HT1B??[Similar Products]

5HT1B_HUMAN

The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) exerts a wide variety of physiologic functions through a multiplicity of receptors and may be involved in human neuropsychiatric disorders such as anxiety, depression, or migraine. These receptors consist of several main groups subdivided into several distinct subtypes on the basis of their pharmacologic characteristics, coupling to intracellular second messengers, and distribution within the nervous system (Zifa and Fillion, 1992 [PubMed 1359584]). The serotonergic receptors belong to the multigene family of receptors coupled to guanine nucleotide-binding proteins.[supplied by OMIM, Oct 2009]

5-HT(1B): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6q13

Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane

Molecular Function: serotonin binding; serotonin receptor activity; drug binding

Biological Process: vasoconstriction; drinking behavior; negative regulation of synaptic transmission, glutamatergic; response to mineralocorticoid stimulus; bone remodeling; response to cocaine; regulation of dopamine secretion; G-protein signaling, coupled to cyclic nucleotide second messenger; negative regulation of serotonin secretion; synaptic transmission; negative regulation of cAMP biosynthetic process; response to ethanol; G-protein coupled receptor internalization; serotonin receptor, adenylate cyclase inhibiting pathway; protein kinase C activation; negative regulation of synaptic transmission, GABAergic; regulation of behavior

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