Product Name
OPA1, Blocking Peptide
Full Product Name
OPA1 Blocking Peptide
Product Synonym Names
KIAA0567; Dynamin-like 120 kDa protein, mitochondrial; Optic atrophy protein 1
Product Gene Name
OPA1 blocking peptide
[Similar Products]
OPA1 peptide (MBS8226328) is used for blocking the activity of OPA1 antibody (MBS8210195)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O60313
Species Reactivity
Human, Mouse, Rat
Form/Format
Lyophilized powder
Quality Control
The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
Directions for Use
Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Other Notes
Small volumes of OPA1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
OPA1 blocking peptide
The peptide is used to block Anti-OPA1 Antibody reactivity.
Applications Tested/Suitable for OPA1 blocking peptide
Blocking (BL)
NCBI/Uniprot data below describe general gene information for OPA1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_056375.2
[Other Products]
NCBI GenBank Nucleotide #
NM_015560.2
[Other Products]
UniProt Primary Accession #
O60313
[Other Products]
UniProt Secondary Accession #
D3DNW4[Other Products]
UniProt Related Accession #
O60313[Other Products]
Molecular Weight
115,884 Da
NCBI Official Full Name
dynamin-like 120 kDa protein, mitochondrial isoform 1
NCBI Official Synonym Full Names
optic atrophy 1 (autosomal dominant)
NCBI Official Symbol
OPA1??[Similar Products]
NCBI Official Synonym Symbols
NPG; NTG; MGM1; largeG
??[Similar Products]
NCBI Protein Information
dynamin-like 120 kDa protein, mitochondrial
UniProt Protein Name
Dynamin-like 120 kDa protein, mitochondrial
UniProt Synonym Protein Names
Optic atrophy protein 1
Protein Family
Dynamin-like 120 kDa protein
UniProt Gene Name
OPA1??[Similar Products]
UniProt Synonym Gene Names
KIAA0567??[Similar Products]
UniProt Entry Name
OPA1_HUMAN
NCBI Summary for OPA1
This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
UniProt Comments for OPA1
OPA1: a dynamin-related GTPase required for mitochondrial fusion and regulation of apoptosis. May form a diffusion barrier for proteins stored in mitochondrial cristae. Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space. Defects in OPA1 are the cause of optic atrophy 1 and deafness. Eight splice-variant isoforms have been described.
Protein type: Apoptosis; Hydrolase; Mitochondrial; Membrane protein, integral; EC 3.6.5.5
Chromosomal Location of Human Ortholog: 3q29
Cellular Component: nucleoplasm; mitochondrial crista; mitochondrial outer membrane; mitochondrion; membrane; dendrite; mitochondrial inner membrane; cytoplasm; integral to membrane; mitochondrial intermembrane space
Molecular Function: GTPase activity; protein binding; GTP binding; magnesium ion binding
Biological Process: inner mitochondrial membrane organization and biogenesis; mitochondrial fission; mitochondrion organization and biogenesis; mitochondrial genome maintenance; axon transport of mitochondrion; visual perception; mitochondrial fusion; metabolic process; apoptosis; neural tube closure
Disease: Glaucoma, Normal Tension, Susceptibility To; Optic Atrophy With Or Without Deafness, Ophthalmoplegia, Myopathy, Ataxia, And Neuropathy; Optic Atrophy 1
Research Articles on OPA1
1. The results of this study indicated that underlying the hearing impairment in patients carrying OPA1 missense mutations is a disordered synchrony in auditory nerve fibre activity resulting from neural degeneration affecting the terminal dendrites.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
