Mouse Monoclonal [clone 1E8-1D9] (IgG) to Human OPA1; OPA1; KIAA0567; MGM1; LargeG; NPG; NTG; Optic atrophy protein 1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

OPA1 antibody detects endogenous levels of OPA1.

Immunoaffinity Purified

PBS, pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol

Store at -20 degree C.

Small volumes of anti-OPA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Dynamin-related GTPase required for mitochondrial fusion and regulationof apoptosis. May form a diffusion barrier for proteins stored inmitochondrial cristae.

ELISA (EIA), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)

ELISA: 1:10000
IHC-P: 1:50
WB: 1:500-1:1000

Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)

Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)

Western blot of extracts from brain tissue, using OPA1 antibody.

107,568 Da

OPA1, mitochondrial dynamin like GTPase

dynamin-like 120 kDa protein, mitochondrial

Dynamin-like 120 kDa protein, mitochondrial

KIAA0567??[Similar Products]

The protein encoded by this gene is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. The encoded protein localizes to the inner mitochondrial membrane and helps regulate mitochondrial stability and energy output. This protein also sequesters cytochrome c. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. [provided by RefSeq, Aug 2017]

Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission (PubMed:16778770, PubMed:17709429, PubMed:20185555, PubMed:24616225). Coexpression of isoform 1 with shorter alternative products is required for optimal activity in promoting mitochondrial fusion (PubMed:17709429). Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation (PubMed:20185555). The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes (PubMed:20185555). Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (). Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space (). Plays a role in mitochondrial genome maintenance (PubMed:20974897, PubMed:18158317).

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