Full Product Name
Rabbit Epo-R (Ab-368) Antibody
Product Gene Name
anti-Epo-R antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 19; NC_000019.9 (11487881..11495018, complement). Location: 19p13.3-p13.2
3D Structure
ModBase 3D Structure for P19235
Species Reactivity
Human, mouse, rat
Form/Format
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Concentration
1 mg/ml (lot specific)
Other Notes
Small volumes of anti-Epo-R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-Epo-R antibody
ELISA (EIA), Immunofluorescence (IF), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for Epo-R. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000112.1
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NCBI GenBank Nucleotide #
NM_000121.3
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UniProt Primary Accession #
P19235
[Other Products]
UniProt Secondary Accession #
Q15443; Q2M205; B2RCG4[Other Products]
UniProt Related Accession #
P19235[Other Products]
Molecular Weight
55,065 Da
NCBI Official Full Name
erythropoietin receptor
NCBI Official Synonym Full Names
erythropoietin receptor
NCBI Official Symbol
EPOR??[Similar Products]
NCBI Official Synonym Symbols
EPO-R
??[Similar Products]
NCBI Protein Information
erythropoietin receptor
UniProt Protein Name
Erythropoietin receptor
UniProt Gene Name
EPOR??[Similar Products]
UniProt Synonym Gene Names
EPO-R??[Similar Products]
UniProt Entry Name
EPOR_HUMAN
NCBI Summary for Epo-R
This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
UniProt Comments for Epo-R
EPOR: erythropoietin receptor: a member of the cytokine receptor family. Mediates erythropoietin-induced erythroblast proliferation, differentiation and survival. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. Forms homodimers on EPO stimulation. Tyrosine-phosphorylated EpoR may bind several SH2 domain-containing proteins including LYN, the adapter protein APS, SHP-1, SHP-2, JAK2, PI3 kinases, STAT5A/B, SOCS3, and CRKL. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Three alternatively-spliced isoforms have been described. Isoform EPOR-T, missing the cytoplasmic tail, acts as a dominant-negative receptor of EPOR-mediated signaling.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 19p13.3-p13.2
Cellular Component: integral to plasma membrane; extracellular region
Molecular Function: identical protein binding; protein binding; erythropoietin receptor activity
Biological Process: heart development; brain development; decidualization; signal transduction
Disease: Erythrocytosis, Familial, 1
Research Articles on Epo-R
1. EPOR expression may be involved in tumor progression and proliferation in HER2-positive breast cancer.EPOR contributes to the mechanism of trastuzumab resistance in breast cancer.
Precautions
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Disclaimer
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