FEPS; ANKTM1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Affinity purification

Store at -20 degree C. Avoid freeze / thaw cycles.

Small volumes of anti-TRPA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control.

Polyclonal

Western Blot (WB)

WB: 1:500 - 1:2000

Western blot analysis of extracts of mouse liver, using TRPA1 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 90s.

Immunohistochemistry of paraffin-embedded rat brain using TRPA1 antibody at dilution of 1:100 (40x lens).

Immunohistochemistry of paraffin-embedded rat heart using TRPA1 antibody at dilution of 1:100 (40x lens).

Immunohistochemistry of paraffin-embedded human prostate using TRPA1 antibody at dilution of 1:100 (40x lens).

Immunohistochemistry of paraffin-embedded human prostate cancer using TRPA1 antibody at dilution of 1:100 (40x lens).

Immunohistochemistry of paraffin-embedded human stomach using TRPA1 antibody at dilution of 1:100 (40x lens).

Immunohistochemistry of paraffin-embedded mouse heart using TRPA1 antibody at dilution of 1:100 (40x lens).

Calculated MW: 128kDa
Molecular Weight: 1119

transient receptor potential cation channel subfamily A member 1

transient receptor potential cation channel subfamily A member 1

Transient receptor potential cation channel subfamily A member 1

ANKTM1??[Similar Products]

TRPA1_HUMAN

The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [provided by RefSeq, Jul 2008]

TRPA1: Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)- tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system. Belongs to the transient receptor (TC 1.A.4) family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 8q13

Cellular Component: integral to plasma membrane; plasma membrane; stereocilium bundle

Molecular Function: channel activity; intracellular ligand-gated calcium channel activity

Biological Process: cell surface receptor linked signal transduction; detection of chemical stimulus involved in sensory perception of pain; detection of mechanical stimulus involved in sensory perception of pain; ion transport; protein homotetramerization; response to cold; response to drug; response to hydrogen peroxide; response to organic cyclic substance; response to organic substance; response to pain; sensory perception of pain; thermoception; transmembrane transport

Disease: Episodic Pain Syndrome, Familial, 1

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