For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Affinity Purified

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-TRPA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This is a rabbit polyclonal antibody against TRPA1. It was validated on Western Blot using a cell lysate as a positive control.

Target Description: The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in sig

Polyclonal; Ion Channel; Membrane Protein; Immunohistochemistry; Receptors;

Immunohistochemistry (IHC), Western Blot (WB), Immunofluorescence (IF)

Immunohistochemistry with rat sensory ganglia tissue

Sample Type :
Section of TRPM8-GFP transgenic mouse trigeminal ganglia
Primary Antibody Dilution :
1:250
Secondary Antibody :
Goat Anti-Rabbit Alexa-Fluor 594
Secondary Antibody Dilution :
1:1000
Color/Signal Descriptions :
TRPA1: Red TRPM8-GFP:: Green
Gene Name :
TRPA1
Submitted by :
Dr. Daniel McCoy, USC

Host: Rabbit
Target Name: TRPA1
Sample Tissue: Human HepG2
Antibody Dilution: 1.0ug/ml

Host: Rabbit
Target Name: TRPA1
Sample Tissue: Human THP-1 Whole Cell
Antibody Dilution: 1ug/ml

WB Suggested Anti-TRPA1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: Human Stomach

127kDa

transient receptor potential cation channel subfamily A member 1

transient receptor potential cation channel subfamily A member 1

Transient receptor potential cation channel subfamily A member 1

ANKTM1??[Similar Products]

TRPA1_HUMAN

The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [provided by RefSeq, Jul 2008]

TRPA1: Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)- tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system. Belongs to the transient receptor (TC 1.A.4) family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 8q13

Cellular Component: stereocilium bundle; integral to plasma membrane; plasma membrane

Molecular Function: channel activity; calcium channel activity

Biological Process: response to drug; detection of mechanical stimulus involved in sensory perception of pain; detection of chemical stimulus involved in sensory perception of pain; response to hydrogen peroxide; response to pain; ion transport; thermoception; response to cold; transmembrane transport

Disease: Episodic Pain Syndrome, Familial, 1

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