5-hydroxytryptamine receptor 1B; 5-HT-1B; 5-HT1B; S12; Serotonin 1D beta receptor; 5-HT-1D-beta; Serotonin receptor 1B; HTR1B; HTR1DB

For Research Use Only. Not for use in diagnostic procedures.

For long term storage, please store the entire kit at -20 degree C.

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Small volumes of HTR1B elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS2880641 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the 5-hydroxytryptamine receptor 1B (HTR1B) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing HTR1B. The ELISA analytical biochemical technique of the MBS2880641 kit is based on HTR1B antibody-HTR1B antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect HTR1B antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, HTR1B. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

43,568 Da

5-hydroxytryptamine receptor 1B

5-hydroxytryptamine receptor 1B

5-hydroxytryptamine receptor 1B

HTR1DB; 5-HT-1B; 5-HT1B; 5-HT-1D-beta??[Similar Products]

5HT1B_HUMAN

The protein encoded by this intronless gene is a G-protein coupled receptor for serotonin (5-hydroxytryptamine). Ligand binding activates second messengers that inhibit the activity of adenylate cyclase and manage the release of serotonin, dopamine, and acetylcholine in the brain. The encoded protein may be involved in several neuropsychiatric disorders and therefore is often a target of antidepressant and other psychotherapeutic drugs. [provided by RefSeq, Nov 2015]

5-HT(1B): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6q13

Cellular Component: cytoplasm; integral to plasma membrane; plasma membrane

Molecular Function: drug binding; protein binding; serotonin binding; serotonin receptor activity

Biological Process: bone remodeling; drinking behavior; G-protein coupled receptor internalization; G-protein signaling, coupled to cyclic nucleotide second messenger; negative regulation of cAMP biosynthetic process; negative regulation of serotonin secretion; negative regulation of synaptic transmission, GABAergic; negative regulation of synaptic transmission, glutamatergic; protein kinase C activation; regulation of behavior; regulation of dopamine secretion; response to cocaine; response to ethanol; response to mineralocorticoid stimulus; serotonin receptor, adenylate cyclase inhibiting pathway; synaptic transmission; vasoconstriction

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