Product Name
Cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1), Recombinant Protein
Full Product Name
Recombinant Sheep Cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1)
Product Gene Name
CYP11A1 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
40-520aa, Full Length of Mature Protein
Sequence
ISTRTPRPYS EIPSPGDNGW INLYHFWRKK GSQRIHFHHI ENFQKYGPIY REKLGNLESV YIIHPEGVAH LFKFEGSYPQ RYDIPPWLAY HRYYQKPIGV LFKKSGAWKK DRVVLNTEVM APEAIKNFIP LLNPVSQDFV SLLHKRIKQQ GSGKFVGDIK EDLFRFAFES ITNVMFGERL GMLEDTVDTE AQKFIDAVYK MFHTSVPLLN LPPELYRLFR TKTWRDHVAA WDTIFNKAEK YTEIFYQDLR QKTEFRNYPG ILYHLLKSEK MLLEDVKANI TEMLAGGVDT TSMTLQWHLY EMARSLNVQE MLRKEVLNAR RQAEGDISKM LQMVPLLKAS IKETLRLHPI SVTLQRYPES DLVLQDYLIP AKTLVQVAIY AMGRDPAFFS NPDKFDPTRW LGKDKDLIHF RNLGFGWGVR QCVGRRIAEL EMTLFLIHIL ENFRVEMQQI GDVNTIFNLI LTPDKPIFLV FRPFNQGPPQ A
3D Structure
ModBase 3D Structure for P79202
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CYP11A1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
CYP11A1 recombinant protein
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide.
NCBI/Uniprot data below describe general gene information for CYP11A1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001087258.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001093789.1
[Other Products]
UniProt Primary Accession #
P79202
[Other Products]
UniProt Related Accession #
P79202[Other Products]
Molecular Weight
60,357 Da
NCBI Official Full Name
cholesterol side-chain cleavage enzyme, mitochondrial
NCBI Official Symbol
CYP11A1??[Similar Products]
NCBI Protein Information
cholesterol side-chain cleavage enzyme, mitochondrial
UniProt Protein Name
Cholesterol side-chain cleavage enzyme, mitochondrial
UniProt Synonym Protein Names
CYPXIA1; Cholesterol desmolase; Cytochrome P450 11A1; Cytochrome P450(scc)
Protein Family
Cholesterol side-chain cleavage enzyme
UniProt Gene Name
CYP11A1??[Similar Products]
UniProt Comments for CYP11A1
Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone, the precursor of most steroid hormones.
Research Articles on CYP11A1
1. Data show that androgenization had effect on a reduction in the expression of StAR, CYP11A, CYP17, and LHR at d 90 of gestation.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
