CCL27; ALP; ILC; CTAK; CTACK; PESKY; ESKINE; SCYA27

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 9; NC_000009.12 (34661896..34662692, complement). Location: 9p13

Monoclonal

IgG1

(7H44)

Mouse

Lyophilized

Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.

Manufactured in an ISO 9001:2008 Certified Laboratory.

Small volumes of anti-CCL-27 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

CTACK or CCL-27 is a keratinocyte-derived CC chemokine which signals through the CCR10 receptor. Both CTACK and CCR10 are expressed in normal and irritated epithelial cells. CTACK selectively attracts CLA+ T-cells and directs them into the skin. CTACK contains the four highly conserved cysteine residues present in most CC chemokines. The mature protein contains 88 amino acid residues. Recombinant human CTACK is a 10.2 kDa protein containing 88 amino acid residues.

Western Blot (WB), Immunohistochemistry (IHC), Neutr

12,618 Da

chemokine (C-C motif) ligand 27

C-C motif chemokine 27; skinkine; CC chemokine ILC; IL-11 Ralpha-locus chemokine; small-inducible cytokine A27; IL-11 R-alpha-locus chemokine; cutaneous T-cell attracting chemokine; cutaneous T-cell-attracting chemokine; small inducible cytokine subfamily A (Cys-Cys), member 27

C-C motif chemokine 27

ILC; SCYA27; CTACK??[Similar Products]

CCL27_HUMAN

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to chemokine receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq, Jul 2008]

Function: Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10.

Subunit structure: Monomer, dimer, and tetramer. Heparin avidly promotes oligomerization. Ref.5

Subcellular location: Secreted.

Tissue specificity: Testis, thymus, placenta, ovary and skin.

Sequence similarities: Belongs to the intercrine beta (chemokine CC) family.

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